PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Arabidopsis thaliana
HD-ZIP Family
Species TF ID Description
AT1G05230.1homeodomain GLABROUS 2
AT1G05230.2homeodomain GLABROUS 2
AT1G05230.3homeodomain GLABROUS 2
AT1G05230.4homeodomain GLABROUS 2
AT1G17920.1homeodomain GLABROUS 12
AT1G26960.1homeobox protein 23
AT1G27045.1HD-ZIP family protein
AT1G30490.1HD-ZIP family protein
AT1G34650.1homeodomain GLABROUS 10
AT1G52150.1HD-ZIP family protein
AT1G52150.2HD-ZIP family protein
AT1G52150.3HD-ZIP family protein
AT1G69780.1HD-ZIP family protein
AT1G70920.1homeobox-leucine zipper protein 18
AT1G73360.1homeodomain GLABROUS 11
AT1G79840.1HD-ZIP family protein
AT1G79840.2HD-ZIP family protein
AT2G01430.1homeobox-leucine zipper protein 17
AT2G18550.1homeobox protein 21
AT2G22430.1homeobox protein 6
AT2G22800.1HD-ZIP family protein
AT2G32370.1homeodomain GLABROUS 3
AT2G34710.1HD-ZIP family protein
AT2G36610.1homeobox protein 22
AT2G44910.1homeobox-leucine zipper protein 4
AT2G46680.1homeobox 7
AT2G46680.2homeobox 7
AT3G01220.1homeobox protein 20
AT3G01470.1homeobox 1
AT3G03260.1homeodomain GLABROUS 8
AT3G60390.1homeobox-leucine zipper protein 3
AT3G61150.1homeodomain GLABROUS 1
AT3G61890.1homeobox 12
AT4G00730.1HD-ZIP family protein
AT4G00730.2HD-ZIP family protein
AT4G04890.1protodermal factor 2
AT4G16780.1homeobox protein 2
AT4G17460.1Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein
AT4G17710.1homeodomain GLABROUS 4
AT4G21750.1HD-ZIP family protein
AT4G21750.2HD-ZIP family protein
AT4G32880.1homeobox gene 8
AT4G36740.1homeobox protein 40
AT4G37790.1HD-ZIP family protein
AT4G40060.1homeobox protein 16
AT5G03790.1homeobox 51
AT5G06710.1homeobox from Arabidopsis thaliana
AT5G15150.1homeobox 3
AT5G17320.1homeodomain GLABROUS 9
AT5G47370.1Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein
AT5G52170.1homeodomain GLABROUS 7
AT5G53980.1homeobox protein 52
AT5G60690.1HD-ZIP family protein
AT5G65310.1homeobox protein 5
AT5G65310.2homeobox protein 5
AT5G66700.1homeobox 53
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401