PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Coffea canephora
bHLH Family
Species TF ID Description
Cc00_g02210bHLH family protein
Cc00_g07200bHLH family protein
Cc00_g12270bHLH family protein
Cc00_g16650bHLH family protein
Cc00_g20690bHLH family protein
Cc00_g24080bHLH family protein
Cc00_g27610bHLH family protein
Cc00_g29370bHLH family protein
Cc00_g30020bHLH family protein
Cc00_g31280bHLH family protein
Cc01_g04410bHLH family protein
Cc01_g10310bHLH family protein
Cc01_g16050bHLH family protein
Cc01_g16390bHLH family protein
Cc01_g17430bHLH family protein
Cc01_g18590bHLH family protein
Cc01_g18880bHLH family protein
Cc01_g19570bHLH family protein
Cc01_g19690bHLH family protein
Cc02_g01870bHLH family protein
Cc02_g03660bHLH family protein
Cc02_g03670bHLH family protein
Cc02_g06200bHLH family protein
Cc02_g08220bHLH family protein
Cc02_g11750bHLH family protein
Cc02_g11910bHLH family protein
Cc02_g11950bHLH family protein
Cc02_g13460bHLH family protein
Cc02_g14830bHLH family protein
Cc02_g16520bHLH family protein
Cc02_g17440bHLH family protein
Cc02_g18940bHLH family protein
Cc02_g19780bHLH family protein
Cc02_g20420bHLH family protein
Cc02_g24640bHLH family protein
Cc02_g26300bHLH family protein
Cc02_g27520bHLH family protein
Cc02_g28190bHLH family protein
Cc02_g28210bHLH family protein
Cc02_g33760bHLH family protein
Cc02_g34000bHLH family protein
Cc02_g34020bHLH family protein
Cc02_g34040bHLH family protein
Cc02_g34070bHLH family protein
Cc02_g34090bHLH family protein
Cc02_g34100bHLH family protein
Cc02_g35090bHLH family protein
Cc02_g35910bHLH family protein
Cc02_g39470bHLH family protein
Cc02_g39830bHLH family protein
Cc03_g03160bHLH family protein
Cc03_g04820bHLH family protein
Cc03_g05370bHLH family protein
Cc03_g07740bHLH family protein
Cc03_g09600bHLH family protein
Cc03_g10250bHLH family protein
Cc03_g14090bHLH family protein
Cc04_g02340bHLH family protein
Cc04_g02910bHLH family protein
Cc04_g08190bHLH family protein
Cc04_g09420bHLH family protein
Cc04_g12140bHLH family protein
Cc04_g13690bHLH family protein
Cc04_g13700bHLH family protein
Cc04_g16030bHLH family protein
Cc04_g16930bHLH family protein
Cc04_g17060bHLH family protein
Cc04_g17160bHLH family protein
Cc05_g00300bHLH family protein
Cc05_g05320bHLH family protein
Cc05_g07290bHLH family protein
Cc05_g07300bHLH family protein
Cc05_g07310bHLH family protein
Cc05_g07320bHLH family protein
Cc05_g08220bHLH family protein
Cc05_g12920bHLH family protein
Cc05_g13180bHLH family protein
Cc06_g01040bHLH family protein
Cc06_g10030bHLH family protein
Cc06_g11520bHLH family protein
Cc06_g15180bHLH family protein
Cc06_g16390bHLH family protein
Cc06_g16420bHLH family protein
Cc06_g17490bHLH family protein
Cc06_g19110bHLH family protein
Cc06_g19820bHLH family protein
Cc07_g03240bHLH family protein
Cc07_g03280bHLH family protein
Cc07_g04540bHLH family protein
Cc07_g06130bHLH family protein
Cc07_g07810bHLH family protein
Cc07_g08110bHLH family protein
Cc07_g09660bHLH family protein
Cc07_g09990bHLH family protein
Cc07_g10760bHLH family protein
Cc07_g14210bHLH family protein
Cc07_g14500bHLH family protein
Cc07_g15720bHLH family protein
Cc08_g01730bHLH family protein
Cc08_g02790bHLH family protein
Cc08_g02950bHLH family protein
Cc08_g13690bHLH family protein
Cc08_g13700bHLH family protein
Cc08_g14790bHLH family protein
Cc08_g16790bHLH family protein
Cc09_g09510bHLH family protein
Cc10_g02500bHLH family protein
Cc10_g04630bHLH family protein
Cc10_g05680bHLH family protein
Cc10_g06580bHLH family protein
Cc10_g07710bHLH family protein
Cc10_g08200bHLH family protein
Cc10_g08760bHLH family protein
Cc10_g08770bHLH family protein
Cc10_g10020bHLH family protein
Cc11_g09940bHLH family protein
Cc11_g10650bHLH family protein
Cc11_g11360bHLH family protein
Cc11_g11510bHLH family protein
Cc11_g13270bHLH family protein
Cc11_g13820bHLH family protein
Cc11_g14670bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250