PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Zmw_sc00647.1.g00320.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Chloridoideae; Zoysieae; Zoysiinae; Zoysia
Family GRF
Protein Properties Length: 626aa    MW: 68518.3 Da    PI: 9.9295
Description GRF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Zmw_sc00647.1.g00320.1genomeZGD-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRC77.11.7e-2494138145
                           WRC   1 daepgrCrRtDGKkWRCsrrvlegkklCErHlhrgrsrsrkskee 45 
                                   d+epgrCrRtDGKkWRCs+++ +++k+CErH+hrgr+rsrk++e+
  Zmw_sc00647.1.g00320.1.am.mk  94 DPEPGRCRRTDGKKWRCSKEAAPDSKYCERHMHRGRNRSRKPVET 138
                                   79****************************************997 PP

2QLQ57.34.6e-201045237
                           QLQ  2 aFTaaQlqlLksQilAyKyLaanqPvPpeLlqaiqk 37
                                  +FT+aQ+++L++Q+l+yKyL+a++ vPp+L+++i++
  Zmw_sc00647.1.g00320.1.am.mk 10 PFTPAQFEELEQQALIYKYLVAGVAVPPDLVVPIRR 45
                                  8*********************************86 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM009516.6E-11945IPR014978Glutamine-Leucine-Glutamine, QLQ
PfamPF088805.7E-141044IPR014978Glutamine-Leucine-Glutamine, QLQ
PROSITE profilePS5166622.0651045IPR014978Glutamine-Leucine-Glutamine, QLQ
PROSITE profilePS5166725.48694138IPR014977WRC domain
PfamPF088797.4E-2195137IPR014977WRC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005524Molecular FunctionATP binding
Sequence ? help Back to Top
Protein Sequence    Length: 626 aa     Download sequence    Send to blast
MSGRWARPLP FTPAQFEELE QQALIYKYLV AGVAVPPDLV VPIRRGLDSL ATRFYGHPTR  60
TVPVLLFYLL LLTTPSLPYR FWLAYGSYFG KKLDPEPGRC RRTDGKKWRC SKEAAPDSKY  120
CERHMHRGRN RSRKPVETQL VPQSQPPSAM APIAAQPLTA ATSGGNFQSH SLYPAIAGSN  180
GGGEGSNISS PFTSSLSSSQ LNLDNTATYA ALGGGTGKDL RYTGYGIRSL ADEHNQLISE  240
AIDSSMANQW RLPPSHNSSF PLPSYPQLGA LSDLGQSTVN SLSKMDRQPL SFLGNDFGTV  300
GSVKQENQLR PFFDEWPKSR ESWPGLGDEN ANLASFSATQ LSMSIPMASS DFSAATPASS  360
QSPNDLYQTK SPDACAADMN GIPSWGTVLR ASDDVTLQLS WAVPRSAWRF PSCERPAPSV  420
GTGDPSPPGI GQLAAHNGAR PVAGSLFPNM IGQQDPWLCH LEPVTSNSRD KIARIDVAIF  480
CSTRVEQWPI GSDREKASRA PMPMALREWG FSENDGANRR RWRRGNAVPH LSSGADRRGR  540
IGHRSRVLRV RVASRHYQSA TVVVAQPRSV TLPSRSAPNT ARPLQRQELG PGLSIEWPFT  600
EGCAHRNVIV IAMPLHLHRY CAVRQL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that plays a role in the regulation of meristematic function in leaves, stems and inflorescences (PubMed:24532604). Transcription activator that plays a regulatory role in grain development (PubMed:26187814, PubMed:27250747, PubMed:27250749, PubMed:26936408, PubMed:27107174). Positively regulates grain size by promoting cell division and expansion, leading to increased grain length and width (PubMed:26187814, PubMed:27250747, PubMed:27250749, PubMed:26936408, PubMed:27107174). Positively regulates the expression of genes promoting cell proliferation (PubMed:26187814, PubMed:26936408). Activates the expression of expansin genes to promote cell expansion and grain size (PubMed:27250747). May promote grain size by activating brassinosteroid responses (PubMed:27250747). Component of a network formed by the microRNA396 (miRNA396), the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation (Probable). Component of the miRNA396c-GRF4-GIF1 regulatory module that plays an important role in grain size determination (Probable) (PubMed:27250747, PubMed:27250749, PubMed:27107174). {ECO:0000269|PubMed:24532604, ECO:0000269|PubMed:26187814, ECO:0000269|PubMed:26936408, ECO:0000269|PubMed:27107174, ECO:0000269|PubMed:27250747, ECO:0000269|PubMed:27250749, ECO:0000305|PubMed:26187814, ECO:0000305|PubMed:27107174, ECO:0000305|PubMed:27250747, ECO:0000305|PubMed:27250749}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: The microRNA396c negatively regulates GRF4 at the transcriptional level. {ECO:0000269|PubMed:26187814, ECO:0000269|PubMed:26936408, ECO:0000269|PubMed:27107174, ECO:0000269|PubMed:27250747}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_025791920.10.0growth-regulating factor 4-like
SwissprotQ6ZIK51e-158GRF4_ORYSJ; Growth-regulating factor 4
TrEMBLA0A1E5VKS70.0A0A1E5VKS7_9POAL; Growth-regulating factor 4 (Fragment)
STRINGSi017449m1e-176(Setaria italica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP24633476
Publications ? help Back to Top
  1. Kikuchi S, et al.
    Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice.
    Science, 2003. 301(5631): p. 376-9
    [PMID:12869764]
  2. Kuijt SJ, et al.
    Interaction between the GROWTH-REGULATING FACTOR and KNOTTED1-LIKE HOMEOBOX families of transcription factors.
    Plant Physiol., 2014. 164(4): p. 1952-66
    [PMID:24532604]
  3. Hu J, et al.
    A Rare Allele of GS2 Enhances Grain Size and Grain Yield in Rice.
    Mol Plant, 2015. 8(10): p. 1455-65
    [PMID:26187814]
  4. Sun P, et al.
    OsGRF4 controls grain shape, panicle length and seed shattering in rice.
    J Integr Plant Biol, 2016. 58(10): p. 836-847
    [PMID:26936408]
  5. Li S, et al.
    The OsmiR396c-OsGRF4-OsGIF1 regulatory module determines grain size and yield in rice.
    Plant Biotechnol. J., 2016. 14(11): p. 2134-2146
    [PMID:27107174]
  6. Che R, et al.
    Control of grain size and rice yield by GL2-mediated brassinosteroid responses.
    Nat Plants, 2015. 2: p. 15195
    [PMID:27250747]
  7. Duan P, et al.
    Regulation of OsGRF4 by OsmiR396 controls grain size and yield in rice.
    Nat Plants, 2015. 2: p. 15203
    [PMID:27250749]