PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GRMZM2G417164_P01
Common NamebHLH82, LOC103635442, ZEAMMB73_537276
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea
Family bHLH
Protein Properties Length: 219aa    MW: 23985.5 Da    PI: 8.5098
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GRMZM2G417164_P01genomeMaizeSequenceView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.31.2e-12250455
                       HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                HLH  4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55
                       +h ++Er+RR+++N+ +  Lr+l P +   + k+ + a+i   A+e+Ik+Lq
  GRMZM2G417164_P01  2 SHIAVERNRRRQMNEHLKVLRSLTPGL---YIKRGDQASIIGGAIEFIKELQ 50
                       89*************************...9********************9 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000832.58E-12154No hitNo description
PROSITE profilePS5088815.135149IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474593.4E-16168IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.102.0E-13261IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000108.5E-10250IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003536.1E-12455IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009913Biological Processepidermal cell differentiation
GO:0010374Biological Processstomatal complex development
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 219 aa     Download sequence    Send to blast
MSHIAVERNR RRQMNEHLKV LRSLTPGLYI KRGDQASIIG GAIEFIKELQ QVLESLEARK  60
KRRSSGGGHS FLTGSPSPTP SPRSHLLSSV STPSPPVMIK ELAACCNSAV ADVEAKISGS  120
NVLLRTLSRR SSIPGRQAVR LIAVLEGLHL EVLHLNISTM EDTVLHSLVL KIGLECQLSV  180
EDLAYEVQQI FGQDTAEQKP QEENHNQHII YSSAMAAAI
Expression -- Microarray ? help Back to Top
Source ID
Expression AtlasGRMZM2G417164
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Strongly expressed in meristemoids and at lower levels in guard mother cells (GMCs) and guard cells. {ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267}.
UniprotTISSUE SPECIFICITY: Leaf epidermis and flowers. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:17183265}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Together with FMA and SPCH, regulates the stomata formation. Required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. Promotes the conversion of the leaf epidermis into stomata. {ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapGRMZM2G417164_P01
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By UV, flagellin, and jasmonic acid (JA) treatments. {ECO:0000269|PubMed:12679534}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKJ7269690.0KJ726969.1 Zea mays clone pUT3670 bHLH transcription factor (bHLH82) gene, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008656121.11e-159transcription factor MUTE
SwissprotQ9M8K61e-68MUTE_ARATH; Transcription factor MUTE
TrEMBLK7V1X71e-157K7V1X7_MAIZE; BHLH transcription factor
STRINGGRMZM2G417164_P011e-158(Zea mays)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP111443441
Representative plantOGRP25315131
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G06120.15e-61bHLH family protein
Publications ? help Back to Top
  1. Casson S,Gray JE
    Influence of environmental factors on stomatal development.
    New Phytol., 2008. 178(1): p. 9-23
    [PMID:18266617]
  2. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  3. Balcerowicz M,Ranjan A,Rupprecht L,Fiene G,Hoecker U
    Auxin represses stomatal development in dark-grown seedlings via Aux/IAA proteins.
    Development, 2014. 141(16): p. 3165-76
    [PMID:25063454]
  4. de Marcos A, et al.
    Transcriptional profiles of Arabidopsis stomataless mutants reveal developmental and physiological features of life in the absence of stomata.
    Front Plant Sci, 2015. 6: p. 456
    [PMID:26157447]
  5. Mahoney AK, et al.
    Functional analysis of the Arabidopsis thaliana MUTE promoter reveals a regulatory region sufficient for stomatal-lineage expression.
    Planta, 2016. 243(4): p. 987-98
    [PMID:26748914]
  6. Klermund C, et al.
    LLM-Domain B-GATA Transcription Factors Promote Stomatal Development Downstream of Light Signaling Pathways in Arabidopsis thaliana Hypocotyls.
    Plant Cell, 2016. 28(3): p. 646-60
    [PMID:26917680]
  7. Fu ZW,Wang YL,Lu YT,Yuan TT
    Nitric oxide is involved in stomatal development by modulating the expression of stomatal regulator genes in Arabidopsis.
    Plant Sci., 2016. 252: p. 282-289
    [PMID:27717464]
  8. Qi X, et al.
    Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling.
    Elife, 2018.
    [PMID:28266915]
  9. Raissig MT, et al.
    Mobile MUTE specifies subsidiary cells to build physiologically improved grass stomata.
    Science, 2017. 355(6330): p. 1215-1218
    [PMID:28302860]
  10. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  11. Han SK, et al.
    MUTE Directly Orchestrates Cell-State Switch and the Single Symmetric Division to Create Stomata.
    Dev. Cell, 2018. 45(3): p. 303-315.e5
    [PMID:29738710]