PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GRMZM2G408012_P01
Organism
Zea mays
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea
Family GRAS
Protein Properties Length: 251aa    MW: 28281.4 Da    PI: 10.7137
Description GRAS family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GRMZM2G408012_P01genomeMaizeSequenceView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1GRAS375e-12181239264
               GRAS   2 velLlecAeavssgdlelaqalLarlselaspdg.dpmqRlaayfteALaarlarsvselykal 64 
                        v +L++cA+ v++ ++  a+ +L rl e+asp+g + m+R+aayf+e L  r+++     +ka+
  GRMZM2G408012_P01 181 VVALTACADSVAACNHDVANYYLVRLGEMASPAGpTLMHRVAAYFVEVLTLRMVH-----AKAF 239
                        568*******************************999****************99.....3333 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd041781.16E-8028172No hitNo description
Gene3DG3DSA:3.40.50.3007.1E-2428172IPR027417P-loop containing nucleoside triphosphate hydrolase
SuperFamilySSF525402.37E-2440172IPR027417P-loop containing nucleoside triphosphate hydrolase
PfamPF019267.0E-12129172IPR006073GTP binding domain
PROSITE profilePS5098510.124154251IPR005202Transcription factor GRAS
PfamPF035141.7E-9181239IPR005202Transcription factor GRAS
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005525Molecular FunctionGTP binding
Sequence ? help Back to Top
Protein Sequence    Length: 251 aa     Download sequence    Send to blast
MVKRSKKSKS KRVTLRQKHK VLRKVKEHDM EKMVTKADPS KRIVLLHNKI DLVPKEAVEK  60
WLTYLREEMP TIAFKCNTQE QRTKPGWKSS KLDKTNSIPQ SSDCLGAENL IRLLKKYSRS  120
HELKLAITVG IVGLPNVGKS SLINSLKRSR VVNVGSTPGV TRSMQEVQLD KKAPMEAMEL  180
VVALTACADS VAACNHDVAN YYLVRLGEMA SPAGPTLMHR VAAYFVEVLT LRMVHAKAFK  240
FAKLHSKNMY Q
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3jct_s1e-2040172205331Nuclear GTP-binding protein NUG1
6elz_s1e-2040172205331Nuclear GTP-binding protein NUG1
6em1_s1e-2040172205331Nuclear GTP-binding protein NUG1
6em5_s1e-2040172205331Nuclear GTP-binding protein NUG1
6ft6_s1e-2040172205331Nuclear GTP-binding protein NUG1
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Zm.48690.0endosperm| meristem| root| shoot
Expression -- Microarray ? help Back to Top
Source ID
Expression AtlasGRMZM2G408012
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Accumulates in developing embryos and in the primordia of cotyledons and leaves (PubMed:22058024). Accumulates mostly in the inflorescence meristem and in floral primordia. Low levels in the inflorescence meristem dome, but high levels in the floral primordia already in early stages. Accumulates progressively in floral organ primordia to become concentrated in the primordia of stamens and carpels. At the later stages of floral development, expressed primarily in developing microspores in the stamens and ovules in the carpels (PubMed:22357616). {ECO:0000269|PubMed:22058024, ECO:0000269|PubMed:22357616}.
UniprotTISSUE SPECIFICITY: Mostly expressed in flowers, siliques and inflorescence apex, and, to a lower extent, in stems and leaves. {ECO:0000269|PubMed:22357616}.
Functional Description ? help Back to Top
Source Description
UniProtInvolved in the differentiation of epidermal cells, probably via the regulation of the expression of meristem-related genes (e.g. CLV3, STM, KNAT1, CUC2 and AG) and of leaf polarity-related genes (e.g. YAB5, FIL, AS2, PHB and PHV) (PubMed:22058024, PubMed:22357616). May play a role in regulating cellular proliferation (By similarity). Necessary for flower development, probably by preventing apical dominance through the down-regulation of AG expression (PubMed:22357616). Required for embryogenesis, leaf and cotyledon development, as well as for leaf polarity establishment (PubMed:22058024). Plays an important role in plant growth and senescence by modulating ribosome biogenesis in nucleolus. Possesses GTPAse activity in vitro. Possesses RNA binding activity in vitro. Associates with ribosomes (PubMed:26163696). {ECO:0000250|UniProtKB:Q8MT06, ECO:0000269|PubMed:22058024, ECO:0000269|PubMed:22357616, ECO:0000269|PubMed:26163696}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapGRMZM2G408012_P01
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0671620.0BT067162.1 Zea mays full-length cDNA clone ZM_BFb0216D03 mRNA, complete cds.
GenBankEU9758450.0EU975845.1 Zea mays clone 502886 guanine nucleotide-binding protein-like 3 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001336610.12e-90uncharacterized protein LOC100275579
SwissprotQ9M8Z51e-67NSN1_ARATH; Guanine nucleotide-binding protein-like NSN1
TrEMBLA0A1D6HCH80.0A0A1D6HCH8_MAIZE; Uncharacterized protein
STRINGGRMZM2G408012_P010.0(Zea mays)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G63100.12e-09GRAS family protein
Publications ? help Back to Top
  1. Hill TA,Broadhvest J,Kuzoff RK,Gasser CS
    Arabidopsis SHORT INTEGUMENTS 2 is a mitochondrial DAR GTPase.
    Genetics, 2006. 174(2): p. 707-18
    [PMID:16849600]
  2. Wang X,Xie B,Zhu M,Zhang Z,Hong Z
    Nucleostemin-like 1 is required for embryogenesis and leaf development in Arabidopsis.
    Plant Mol. Biol., 2012. 78(1-2): p. 31-44
    [PMID:22058024]
  3. Jeon Y, et al.
    The nucleolar GTPase nucleostemin-like 1 plays a role in plant growth and senescence by modulating ribosome biogenesis.
    J. Exp. Bot., 2015. 66(20): p. 6297-310
    [PMID:26163696]
  4. Zhao H, et al.
    The Arabidopsis gene DIG6 encodes a large 60S subunit nuclear export GTPase 1 that is involved in ribosome biogenesis and affects multiple auxin-regulated development processes.
    J. Exp. Bot., 2015. 66(21): p. 6863-75
    [PMID:26272902]
  5. Wang Z,Wang X,Xie B,Hong Z,Yang Q
    Arabidopsis NUCLEOSTEMIN-LIKE 1 (NSN1) regulates cell cycling potentially by cooperating with nucleosome assembly protein AtNAP1;1.
    BMC Plant Biol., 2018. 18(1): p. 99
    [PMID:29859040]
  6. Fu G,Melville S,Brewster S,Warner J,Barker DC
    Analysis of the genomic organisation of a small chromosome of Leishmania braziliensis M2903 reveals two genes encoding GTP-binding proteins, one of which belongs to a new G-protein family and is an antigen.
    Gene, 1998. 210(2): p. 325-33
    [PMID:9573393]