PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GRMZM2G078954_P01
Common NameZm.137096
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea
Family NAC
Protein Properties Length: 672aa    MW: 73548.1 Da    PI: 9.1013
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GRMZM2G078954_P01genomeMaizeSequenceView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM101.11.5e-313184561128
                NAM   1 lppGfrFhPtdeelvveyLkkkvegkk......leleev.ikev.diykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratk....s 80 
                        lp+G++F+P+d+el+++ ++k+  ++       ++++   ++e  +i++++P++Lp  vk++ +  +fF+++ k+y+tg+rk+r ++    +
  GRMZM2G078954_P01 318 LPKGVKFDPSDQELIWHLMAKH-GKSGikphpfIDEFIPtVEEDeGICYTHPQKLP-GVKQNGSVSHFFHRTFKAYNTGTRKRRRINtddaD 407
                        799************7666554.44443555442322222333336**********.667778899*****************964434667 PP

                NAM  81 gyWkatgkdkevlskkgelvglkktLvfy..kgrapkgektdWvmheyrl 128
                         +W++tgk+k+vl+ +g++ g+kk++v+y    +  k+ekt+Wv+h+y+l
  GRMZM2G078954_P01 408 VRWHKTGKTKPVLV-DGKHLGCKKIMVLYisPLKGGKAEKTNWVIHQYHL 456
                        89************.999***********6523777778*********98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019411.83E-35306475IPR003441NAC domain
PROSITE profilePS5100530.849318475IPR003441NAC domain
PfamPF023655.4E-13319456IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 672 aa     Download sequence    Send to blast
MVRGPVPTVG AGGTPYTPPT VLEEATPPSW VAGEELFRRG NLSSDSISGL AFALPHESGF  60
PQTGLSRRVL RTGSSQGGDG GSLVGDRWRG RRRINDRRRG DWRGRVLRTG NPRRRGICHS  120
RKDRCGARRG EGPSGGNGPC PPRRPKHSSS GRRDGGGSTK RRGPYPGREG RELGIHGRRE  180
DPGALAALGG VWSGGTEAGR AGARTWALLA GAARLLAALA WDRGRAGPGE QSGALAALPC  240
ARRGRGRVGP PKAGRGGQSG APGRSGWVRP LAGAAAGAGG APGRDDGSRE GRWRLHREGR  300
WNPWLDTMSQ VVHQWPGLPK GVKFDPSDQE LIWHLMAKHG KSGIKPHPFI DEFIPTVEED  360
EGICYTHPQK LPGVKQNGSV SHFFHRTFKA YNTGTRKRRR INTDDADVRW HKTGKTKPVL  420
VDGKHLGCKK IMVLYISPLK GGKAEKTNWV IHQYHLGTGE DERDGEYVVS KLFFQQQFKP  480
GDKNAQELTT SDDLESMAAE SNLPDFTTLP TDKHVGTVQE VVHNPEHNLY QLNRNCEISI  540
EETVVLPPSV KTTKDGDNLQ SQDQKLWEGD SQFELLDSQQ LAEGLALCDE FLLSQSQTSC  600
GGGDEPRETK PCLAAYAHLS AEDFKKDLEC QRLEPTDNTN LELDNTDEFR LSQIEFSQDS  660
FMTWAAEKIT DD
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1395399RKRRR
2396400KRRRI
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Zm.202690.0meristem| ovary| pollen| shoot| tassel
Expression -- Microarray ? help Back to Top
Source ID
Expression AtlasGRMZM2G078954
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in shoot and root apical meristems, in lateral root primordia, in the vasculature of young leaves and in the root stele. {ECO:0000269|PubMed:23907539}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269|PubMed:19549833, ECO:0000269|PubMed:20634150, ECO:0000269|PubMed:24399300, ECO:0000305|PubMed:24736489}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapGRMZM2G078954_P01
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269|PubMed:23907539}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0558620.0BT055862.1 Zea mays full-length cDNA clone ZM_BFb0341H11 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001348999.10.0uncharacterized protein LOC100280252
SwissprotQ6NQK21e-109NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBLA0A1D6LWF70.0A0A1D6LWF7_MAIZE; NAC domain-containing protein 8
STRINGGRMZM2G078954_P010.0(Zea mays)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP67853651
Representative plantOGRP82641016
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G25580.11e-111NAC family protein
Publications ? help Back to Top
  1. Yi D, et al.
    The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species.
    Plant Cell, 2014. 26(1): p. 296-309
    [PMID:24399300]
  2. Biever JJ,Brinkman D,Gardner G
    UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation.
    J. Exp. Bot., 2014. 65(11): p. 2949-61
    [PMID:24591052]
  3. Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L
    Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links.
    Plant Cell, 2015. 27(1): p. 149-61
    [PMID:25595823]
  4. Chen P,Umeda M
    DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana.
    Genes Cells, 2015. 20(8): p. 636-46
    [PMID:26033196]
  5. Sjogren CA,Bolaris SC,Larsen PB
    Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response.
    Plant Cell, 2015. 27(9): p. 2501-15
    [PMID:26320227]
  6. Yoshiyama KO
    SOG1: a master regulator of the DNA damage response in plants.
    Genes Genet. Syst., 2016. 90(4): p. 209-16
    [PMID:26617076]
  7. Weimer AK, et al.
    The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis.
    EMBO J., 2016. 35(19): p. 2068-2086
    [PMID:27497297]
  8. Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M
    DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana.
    Genes Cells, 2016. 21(11): p. 1195-1208
    [PMID:27658920]
  9. Pedroza-GarcĂ­a JA, et al.
    Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis.
    Plant Physiol., 2017. 173(3): p. 1735-1749
    [PMID:28153919]
  10. Horvath BM, et al.
    Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control.
    EMBO J., 2017. 36(9): p. 1261-1278
    [PMID:28320736]
  11. Sjogren CA,Larsen PB
    SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis.
    Plant Cell Environ., 2017. 40(9): p. 1849-1860
    [PMID:28556304]
  12. Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S
    Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana.
    Plant Cell, 2017. 29(12): p. 3255-3268
    [PMID:29208704]
  13. Johnson RA, et al.
    SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration.
    Plant Physiol., 2018. 176(2): p. 1665-1675
    [PMID:29222192]
  14. Ogita N, et al.
    Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis.
    Plant J., 2018. 94(3): p. 439-453
    [PMID:29430765]
  15. Cao X, et al.
    Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots.
    Chemosphere, 2018. 201: p. 586-594
    [PMID:29533809]