PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GRMZM2G017087_P03
Common Namekn1
Organism
Zea mays
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea
Family TALE
Protein Properties Length: 193aa    MW: 22580.5 Da    PI: 7.4198
Description TALE family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GRMZM2G017087_P03genomeMaizeSequenceView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox28.82.1e-091221562155
                        HSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHH CS
           Homeobox  21 knrypsaeereeLAkklgLterqVkvWFqNrRake 55 
                        k +yps++++  LA+++gL+ +q+ +WF N+R ++
  GRMZM2G017087_P03 122 KWPYPSETQKVALAESTGLDLKQINNWFINQRKRH 156
                        569*****************************885 PP
2ELK38.23e-137697122
                ELK  1 ELKhqLlrKYsgyLgsLkqEFs 22
                       ELKh+Ll+KYsgyL+sLkqE+s
  GRMZM2G017087_P03 76 ELKHHLLKKYSGYLSSLKQELS 97
                       9*******************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF037913.9E-16136IPR005541KNOX2
SMARTSM012563.6E-13138IPR005541KNOX2
PfamPF037893.6E-107697IPR005539ELK domain
PROSITE profilePS5121311.3317696IPR005539ELK domain
SMARTSM011884.9E-77697IPR005539ELK domain
PROSITE profilePS5007112.69896159IPR001356Homeobox domain
SuperFamilySSF466892.27E-2097171IPR009057Homeodomain-like
SMARTSM003891.6E-1298163IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.604.4E-29101161IPR009057Homeodomain-like
CDDcd000861.90E-11108160No hitNo description
PfamPF059204.8E-17116155IPR008422Homeobox KN domain
PROSITE patternPS000270134157IPR017970Homeobox, conserved site
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 193 aa     Download sequence    Send to blast
MEAYHEMLVK FREELTRPLQ EAMEFMRRVE SQLNSLSISG RSLRNILSSG SSEEDQEGSG  60
GETELPEVDA HGVDQELKHH LLKKYSGYLS SLKQELSKKK KKGKLPKEAR QQLLSWWDQH  120
YKWPYPSETQ KVALAESTGL DLKQINNWFI NQRKRHWKPS EEMHHLMMDG YHTTNAFYMD  180
GHFINDGGLY RLG
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Zm.947100.0ear| meristem| ovary| shoot| tassel
Expression -- Microarray ? help Back to Top
Source ID
Expression AtlasGRMZM2G017087
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed throughout apical and vegetative meristem during development. Down-regulated as leaves and floral organs are initiated. {ECO:0000269|PubMed:1362381}.
UniprotTISSUE SPECIFICITY: Expressed in apical meristems of vegetative and floral stems as well as in the underlying ground meristem. Specifically expressed in vascular bundles developing both in the leaf and stem. Very low levels of expression in leaves.
Functional Description ? help Back to Top
Source Description
UniProtBinds to RNA (PubMed:17965274). Possible transcription factor that regulates genes involved in development. Mutations in KN-1 alter leaf development. Foci of cells along the lateral vein do not differentiate properly but continue to divide, forming knots. May participate in the switch from indeterminate to determinate cell fates. Probably binds to the DNA sequence 5'-TGAC-3'. {ECO:0000269|PubMed:17965274}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00675ChIP-seqSRX158000Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapGRMZM2G017087_P03
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankEU9619520.0EU961952.1 Zea mays clone 239250 homeobox protein OSH1 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001266662.21e-140homeotic protein knotted-1
SwissprotP243451e-141KN1_MAIZE; Homeotic protein knotted-1
TrEMBLA0A1D6L2Y01e-141A0A1D6L2Y0_MAIZE; Homeotic protein knotted-1
STRINGGRMZM2G017087_P021e-140(Zea mays)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G08150.13e-60KNOTTED-like from Arabidopsis thaliana
Publications ? help Back to Top
  1. Lowe B,Mathern J,Hake S
    Active Mutator elements suppress the knotted phenotype and increase recombination at the Kn1-O tandem duplication.
    Genetics, 1992. 132(3): p. 813-22
    [PMID:1334895]
  2. Sinha N,Hake S
    Mutant characters of knotted maize leaves are determined in the innermost tissue layers.
    Dev. Biol., 1990. 141(1): p. 203-10
    [PMID:2391001]
  3. Chen H,Jackson D,Kim JY
    Identification of evolutionarily conserved amino acid residues in homeodomain of KNOX proteins for intercellular trafficking.
    Plant Signal Behav, 2014. 9(3): p. e28355
    [PMID:24603432]
  4. Sinha NR,Williams RE,Hake S
    Overexpression of the maize homeo box gene, KNOTTED-1, causes a switch from determinate to indeterminate cell fates.
    Genes Dev., 1993. 7(5): p. 787-95
    [PMID:7684007]
  5. Greene B,Walko R,Hake S
    Mutator insertions in an intron of the maize knotted1 gene result in dominant suppressible mutations.
    Genetics, 1994. 138(4): p. 1275-85
    [PMID:7896105]
  6. Mathern J,Hake S
    Mu element-generated gene conversions in maize attenuate the dominant knotted phenotype.
    Genetics, 1997. 147(1): p. 305-14
    [PMID:9286690]