PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GRMZM2G017087_P01
Common Namekn1
Organism
Zea mays
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea
Family TALE
Protein Properties Length: 343aa    MW: 37818.7 Da    PI: 6.8512
Description TALE family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GRMZM2G017087_P01genomeMaizeSequenceView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox26.11.5e-082723062155
                        HSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHH CS
           Homeobox  21 knrypsaeereeLAkklgLterqVkvWFqNrRake 55 
                        k +yps++++  LA+++gL+ +q+ +WF N+R ++
  GRMZM2G017087_P01 272 KWPYPSETQKVALAESTGLDLKQINNWFINQRKRH 306
                        569*****************************885 PP
2ELK37.26.3e-13226247122
                ELK   1 ELKhqLlrKYsgyLgsLkqEFs 22 
                        ELKh+Ll+KYsgyL+sLkqE+s
  GRMZM2G017087_P01 226 ELKHHLLKKYSGYLSSLKQELS 247
                        9*******************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM012551.1E-1886130IPR005540KNOX1
PfamPF037901.1E-2187128IPR005540KNOX1
SMARTSM012561.9E-27137188IPR005541KNOX2
PfamPF037918.4E-23143186IPR005541KNOX2
SMARTSM01188570146166IPR005539ELK domain
PROSITE profilePS5121311.331226246IPR005539ELK domain
SMARTSM011884.9E-7226247IPR005539ELK domain
PfamPF037897.7E-10226247IPR005539ELK domain
PROSITE profilePS5007112.698246309IPR001356Homeobox domain
SuperFamilySSF466897.27E-20247321IPR009057Homeodomain-like
SMARTSM003891.6E-12248313IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.601.3E-28251311IPR009057Homeodomain-like
CDDcd000862.29E-12258310No hitNo description
PfamPF059201.1E-16266305IPR008422Homeobox KN domain
PROSITE patternPS000270284307IPR017970Homeobox, conserved site
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 343 aa     Download sequence    Send to blast
MATASTTIIT TTTTRGHPPL SAVVAPLPPQ PPSAGLPLTL NTVAATGNSG GSGNPVLQLA  60
NGGGLLDACV KAKEPSSSSP YAGDVEAIKA KIISHPHYYS LLTAYLECNK VGAPPEVSAR  120
LTEIAQEVEA RQRTALGGLA AATEPELDQF MEAYHEMLVK FREELTRPLQ EAMEFMRRVE  180
SQLNSLSISG RSLRNILSSG SSEEDQEGSG GETELPEVDA HGVDQELKHH LLKKYSGYLS  240
SLKQELSKKK KKGKLPKEAR QQLLSWWDQH YKWPYPSETQ KVALAESTGL DLKQINNWFI  300
NQRKRHWKPS EEMHHLMMDG YHTTNAFYMD GHFINDGGLY RLG
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Zm.947100.0ear| meristem| ovary| shoot| tassel
Expression -- Microarray ? help Back to Top
Source ID
Expression AtlasGRMZM2G017087
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed throughout apical and vegetative meristem during development. Down-regulated as leaves and floral organs are initiated. {ECO:0000269|PubMed:1362381}.
UniprotTISSUE SPECIFICITY: Expressed in apical meristems of vegetative and floral stems as well as in the underlying ground meristem. Specifically expressed in vascular bundles developing both in the leaf and stem. Very low levels of expression in leaves.
Functional Description ? help Back to Top
Source Description
UniProtBinds to RNA (PubMed:17965274). Possible transcription factor that regulates genes involved in development. Mutations in KN-1 alter leaf development. Foci of cells along the lateral vein do not differentiate properly but continue to divide, forming knots. May participate in the switch from indeterminate to determinate cell fates. Probably binds to the DNA sequence 5'-TGAC-3'. {ECO:0000269|PubMed:17965274}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00675ChIP-seqSRX158000Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapGRMZM2G017087_P01
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankEU9619520.0EU961952.1 Zea mays clone 239250 homeobox protein OSH1 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001266662.20.0homeotic protein knotted-1
SwissprotP243450.0KN1_MAIZE; Homeotic protein knotted-1
TrEMBLQ53ZF10.0Q53ZF1_MAIZE; Homeobox protein OSH1
STRINGGRMZM2G017087_P020.0(Zea mays)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G08150.14e-91KNOTTED-like from Arabidopsis thaliana
Publications ? help Back to Top
  1. Lowe B,Mathern J,Hake S
    Active Mutator elements suppress the knotted phenotype and increase recombination at the Kn1-O tandem duplication.
    Genetics, 1992. 132(3): p. 813-22
    [PMID:1334895]
  2. Sinha N,Hake S
    Mutant characters of knotted maize leaves are determined in the innermost tissue layers.
    Dev. Biol., 1990. 141(1): p. 203-10
    [PMID:2391001]
  3. Chen H,Jackson D,Kim JY
    Identification of evolutionarily conserved amino acid residues in homeodomain of KNOX proteins for intercellular trafficking.
    Plant Signal Behav, 2014. 9(3): p. e28355
    [PMID:24603432]
  4. Sinha NR,Williams RE,Hake S
    Overexpression of the maize homeo box gene, KNOTTED-1, causes a switch from determinate to indeterminate cell fates.
    Genes Dev., 1993. 7(5): p. 787-95
    [PMID:7684007]
  5. Greene B,Walko R,Hake S
    Mutator insertions in an intron of the maize knotted1 gene result in dominant suppressible mutations.
    Genetics, 1994. 138(4): p. 1275-85
    [PMID:7896105]
  6. Mathern J,Hake S
    Mu element-generated gene conversions in maize attenuate the dominant knotted phenotype.
    Genetics, 1997. 147(1): p. 305-14
    [PMID:9286690]