PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 678389604
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lentibulariaceae; Utricularia
Family E2F/DP
Protein Properties Length: 560aa    MW: 62427.9 Da    PI: 4.6697
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
678389604genomeUGSPView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.22.5e-27222287171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  678389604 222 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 287
                6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.0E-29220288IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467855.98E-17222285IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.2E-35222287IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.0E-24224287IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146606.85E-47298404No hitNo description
SuperFamilySSF1440748.89E-33301404No hitNo description
PfamPF164212.6E-33304402IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 560 aa     Download sequence    Send to blast
MVLPSNVYPN RIPWLITPFP RFPLSVALIR SPTTHYDFFR NFPFYLHSVT LPANPSLRSG  60
FGTSNPLRSY GFDEFSLLGP PAHGTRLRMQ PAEKQPMRRQ LMVASTTAPF GRGGGGEYEY  120
HHFVDDETRK PTQDFDEAIV LRTPPQLKRK SGKTDSDVDS WKLGGSGSVS TLQVSSQTPP  180
TGKSGKTQRV SRTTKTSKAG SQVPMPNIGS PSGNNLTPGP CRYDSSLGLL TKKFINLIKH  240
AEDGILDLNK AADTLEVQKR RIYDITNVLE GIGLIEKKLK NRIQWKGIDV HRPGDDEESL  300
PRFQEDVENL NIEEQNLDER IREMQEKLRG LSEDNNNQKW LFVTEEDIKG LPCFQNETLI  360
AIKAPHGTTL EVPDPDEAVD YPQRRYQIVL RSTMGPIDVY LVSQFVENID ENNSSDMQEN  420
VPEMLPTEEH PSNPIPIEEI QGNECDLQQT EHQRMCSGAS TSQDFPTGIM KIIPDVDDDA  480
DYWLLSDADT SLTNMWGVES GVDWNSLETV LEDQLMLCIP TSPAGTPPPP GAGDLPCDFP  540
QHQNSPLGTE TASATSGNRI
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-26218288274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMap678389604
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011090314.10.0transcription factor E2FB isoform X1
SwissprotQ9FV711e-129E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A068UEG00.0A0A068UEG0_COFCA; Uncharacterized protein
TrEMBLA0A2R6P7350.0A0A2R6P735_ACTCH; Transcription factor E2FB like
STRINGMigut.N02463.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-129E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]