PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Tp_un0036_004

Organism

Thellungiella parvula

Taxonomic ID

98039

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassicaceae incertae sedis; Schrenkiella

Family

bHLH

Protein Properties

Length: 606aa MW: 66696.9 Da PI: 4.7098

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Tp_un0036_004	genome	thellungiella	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	39.4	1.1e-12	431	476	4	54
HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS HLH 4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 +h e+Er+RR+++N++f Lr ++P+ K++Ka+ L A+ YI++L Tp_un0036_004 431 NHVEAERQRREKLNQRFYSLRAVVPNV-----SKMDKASLLGDAISYINEL 476 799*********************6.....5*************998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Pfam	PF14215	5.8E-55	51	236	IPR025610	Transcription factor MYC/MYB N-terminal
PROSITE profile	PS50888	17.282	427	476	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	2.75E-18	430	496	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	8.86E-15	430	481	No hit	No description
Gene3D	G3DSA:4.10.280.10	4.5E-18	431	495	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	4.0E-10	431	476	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	9.8E-17	433	482	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006952	Biological Process	defense response
GO:0009718	Biological Process	anthocyanin-containing compound biosynthetic process
GO:0009753	Biological Process	response to jasmonic acid
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0043425	Molecular Function	bHLH transcription factor binding
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 606 aa Download sequence Send to blast
MNDYFLNQST ATDDNASAAM EAFIGTNHST IWPQPSLPPP PPLSQFNEDT LQQRLQALIE 60 SAGESWTYAI FWQISHDFDS PTGENTVVLG WGDGYYKGEE DKEKKKKSST SNAAEQEHRK 120 RVIRELNSLI SGGIGVSDES NDEEVTDTEW FFLVSMTQSF ANGVGLPGES FLNSRVIWLS 180 GSGALTGSGC ERAGQGQIYG LQTMVCIAAE NGVVELGSSE LINQSSDLMD KVNNLFNFDN 240 GNGGEACSWG INLNPDQGEN DPAMWISEPM TTGIEPGQVT PAINNSNSNS SSKSDTHQIS 300 KLEKNESSIE NPRQQQNPSL VERDLNFSSS GLNQNGNFQD GSSRMMMKSN ETLSFMAEES 360 NKRRSPVSKG SNNDEAMLSF STVVRSAPKS GDSDHSDLEA SVVKEAIVVE PEKKPRKRGR 420 KPANGREEPL NHVEAERQRR EKLNQRFYSL RAVVPNVSKM DKASLLGDAI SYINELKSKL 480 QQAESDKEEI QKQLDGMSKE GNGKGGVSRA KERKCSNQDS ASSIEMEIDV KIIGWDVMIR 540 VQCSKKNHPG ARFMEALKEL DLEVNHASLS VVNDLMIQQA TVKMGSQFFN HDQLKAVLVS 600 KVGEEN

Sequence ? help Back to Top

Protein Sequence Length: 606 aa Download sequence Send to blast

MNDYFLNQST ATDDNASAAM EAFIGTNHST IWPQPSLPPP PPLSQFNEDT LQQRLQALIE  60
SAGESWTYAI FWQISHDFDS PTGENTVVLG WGDGYYKGEE DKEKKKKSST SNAAEQEHRK  120
RVIRELNSLI SGGIGVSDES NDEEVTDTEW FFLVSMTQSF ANGVGLPGES FLNSRVIWLS  180
GSGALTGSGC ERAGQGQIYG LQTMVCIAAE NGVVELGSSE LINQSSDLMD KVNNLFNFDN  240
GNGGEACSWG INLNPDQGEN DPAMWISEPM TTGIEPGQVT PAINNSNSNS SSKSDTHQIS  300
KLEKNESSIE NPRQQQNPSL VERDLNFSSS GLNQNGNFQD GSSRMMMKSN ETLSFMAEES  360
NKRRSPVSKG SNNDEAMLSF STVVRSAPKS GDSDHSDLEA SVVKEAIVVE PEKKPRKRGR  420
KPANGREEPL NHVEAERQRR EKLNQRFYSL RAVVPNVSKM DKASLLGDAI SYINELKSKL  480
QQAESDKEEI QKQLDGMSKE GNGKGGVSRA KERKCSNQDS ASSIEMEIDV KIIGWDVMIR  540
VQCSKKNHPG ARFMEALKEL DLEVNHASLS VVNDLMIQQA TVKMGSQFFN HDQLKAVLVS  600
KVGEEN

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4rru_A	1e-119	6	232	4	227	Transcription factor MYC3
4ywc_A	1e-119	6	232	4	227	Transcription factor MYC3
4ywc_B	1e-119	6	232	4	227	Transcription factor MYC3
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Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	412	420	KKPRKRGRK

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. With MYC2 and MYC4, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters. {ECO:0000269\|PubMed:12136026, ECO:0000269\|PubMed:21242320, ECO:0000269\|PubMed:21321051, ECO:0000269\|PubMed:21335373, ECO:0000269\|PubMed:23943862}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00085	PBM	Transfer from AT5G46760	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Barely up-regulated by jasmonic acid. {ECO:0000269\|PubMed:21242320, ECO:0000269\|PubMed:21335373}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	-	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK352707	0.0	AK352707.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-05-E20.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_024010949.1	0.0	transcription factor MYC3
Swissprot	Q9FIP9	0.0	MYC3_ARATH; Transcription factor MYC3
TrEMBL	E4MW10	0.0	E4MW10_EUTHA; mRNA, clone: RTFL01-05-E20
STRING	XP_006398371.1	0.0	(Eutrema salsugineum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM1265	28	96

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G46760.1	0.0	bHLH family protein

Publications ? help Back to Top
Chico JM, et al. Repression of Jasmonate-Dependent Defenses by Shade Involves Differential Regulation of Protein Stability of MYC Transcription Factors and Their JAZ Repressors in Arabidopsis. Plant Cell, 2014. 26(5): p. 1967-1980 [PMID:24824488] Gasperini D, et al. Multilayered Organization of Jasmonate Signalling in the Regulation of Root Growth. PLoS Genet., 2015. 11(6): p. e1005300 [PMID:26070206] Qi T, et al. Regulation of Jasmonate-Induced Leaf Senescence by Antagonism between bHLH Subgroup IIIe and IIId Factors in Arabidopsis. Plant Cell, 2015. 27(6): p. 1634-49 [PMID:26071420] de Torres Zabala M, et al. Novel JAZ co-operativity and unexpected JA dynamics underpin Arabidopsis defence responses to Pseudomonas syringae infection. New Phytol., 2016. 209(3): p. 1120-34 [PMID:26428397] Yu J, et al. JAZ7 negatively regulates dark-induced leaf senescence in Arabidopsis. J. Exp. Bot., 2016. 67(3): p. 751-62 [PMID:26547795] Chen X,Huang H,Qi T,Liu B,Song S New perspective of the bHLH-MYB complex in jasmonate-regulated plant fertility in arabidopsis. Plant Signal Behav, 2016. 11(2): p. e1135280 [PMID:26829586] Schmiesing A,Emonet A,Gouhier-Darimont C,Reymond P Arabidopsis MYC Transcription Factors Are the Target of Hormonal Salicylic Acid/Jasmonic Acid Cross Talk in Response to Pieris brassicae Egg Extract. Plant Physiol., 2016. 170(4): p. 2432-43 [PMID:26884488] Thatcher LF, et al. Characterization of a JAZ7 activation-tagged Arabidopsis mutant with increased susceptibility to the fungal pathogen Fusarium oxysporum. J. Exp. Bot., 2016. 67(8): p. 2367-86 [PMID:26896849] Gao C, et al. MYC2, MYC3, and MYC4 function redundantly in seed storage protein accumulation in Arabidopsis. Plant Physiol. Biochem., 2016. 108: p. 63-70 [PMID:27415132] Gimenez-Ibanez S, et al. JAZ2 controls stomata dynamics during bacterial invasion. New Phytol., 2017. 213(3): p. 1378-1392 [PMID:28005270] Zhang F, et al. Structural insights into alternative splicing-mediated desensitization of jasmonate signaling. Proc. Natl. Acad. Sci. U.S.A., 2017. 114(7): p. 1720-1725 [PMID:28137867] Lian TF,Xu YP,Li LF,Su XD Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA. Cell Rep, 2017. 19(7): p. 1334-1342 [PMID:28514654] Wang H, et al. The bHLH Transcription Factors MYC2, MYC3, and MYC4 Are Required for Jasmonate-Mediated Inhibition of Flowering in Arabidopsis. Mol Plant, 2017. 10(11): p. 1461-1464 [PMID:28827172] Song S, et al. MYC5 is Involved in Jasmonate-Regulated Plant Growth, Leaf Senescence and Defense Responses. Plant Cell Physiol., 2017. 58(10): p. 1752-1763 [PMID:29017003] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884]