PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Tp6g07700
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassicaceae incertae sedis; Schrenkiella
Family bHLH
Protein Properties Length: 517aa    MW: 58692.3 Da    PI: 5.3899
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Tp6g07700genomethellungiellaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH42.21.5e-13363408454
                HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
        HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                +h  +ErrRR+++N++f +Lr+l+P       +K++K++iL  +++Y+++L
  Tp6g07700 363 NHVVAERRRREKLNERFITLRSLVPFV-----TKMDKVSILGDTIDYVNHL 408
                6999**********************8.....8****************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142155.5E-5320197IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.396359408IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.44E-18362426IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.29E-13362408No hitNo description
Gene3DG3DSA:4.10.280.108.1E-19363426IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000105.6E-11363408IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.6E-17365414IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS516718.696448517IPR002912ACT domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010026Biological Processtrichome differentiation
GO:0010214Biological Processseed coat development
GO:2000029Biological Processregulation of proanthocyanidin biosynthetic process
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 517 aa     Download sequence    Send to blast
MEESSIIAAE KVIGAEKIEL QGLLKAVVKS VEWTYSLFWQ LCPQQRVLVW GNGYYNGAIK  60
TRKTTQPAEV TAEEAALERS QQLRELYETL LAGESSTEAR ACTALSPEDL TETEWFYLMC  120
VSFSFTPPSG MPGKAYARRK HVWLSGANEV DSKIFSRAIL AKQTVVCIPM LDGVVELGST  180
NKVKESLEFV EHIKSFFHNH PKSNPKPALS EHSINEAHEE DEEEEVEEEM TMSEEIRLGS  240
PDDDDISNQN LLSDFHIEST NTLDAHMDMM NLVEEGGNYS QTVSTLLMSQ PTGLLSDSVS  300
TSSYVQSSFS TWTVENLSEG QHHQRVDNAS SSSSQWLLKH MIFRVPFLHD NTKDKRLPRE  360
ELNHVVAERR RREKLNERFI TLRSLVPFVT KMDKVSILGD TIDYVNHLCK RVHELETSHH  420
QQQHKRMRTS KGKTLEVVEV SIIESDVLLE MRCEYQDGLL LDILQVLKEL GIETTAVHTA  480
VNDHDFEAEI RAKVRGKKPS IAEVKRAIHQ IISNTKL
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A4e-21201989193Transcription factor MYC3
4rqw_B4e-21201989193Transcription factor MYC3
4rs9_A4e-21201989193Transcription factor MYC3
4yz6_A4e-21201989193Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1367372ERRRRE
2368373RRRREK
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator, when associated with MYB75/PAP1 or MYB90/PAP2. Involved in the control of flavonoid pigmentation. Plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). Not required for leucoanthocyanidin dioxygenase (LDOX) expression. {ECO:0000269|PubMed:15361138}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapTp6g07700
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024009789.10.0transcription factor TT8
SwissprotQ9FT810.0TT8_ARATH; Transcription factor TT8
TrEMBLV4LFR20.0V4LFR2_EUTSA; Uncharacterized protein
STRINGXP_006397140.10.0(Eutrema salsugineum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM94222836
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G09820.10.0bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Kim K,Jiang K,Teng SL,Feldman LJ,Huang H
    Using biologically interrelated experiments to identify pathway genes in Arabidopsis.
    Bioinformatics, 2012. 28(6): p. 815-22
    [PMID:22271267]
  3. Liu Z,Shi MZ,Xie DY
    Regulation of anthocyanin biosynthesis in Arabidopsis thaliana red pap1-D cells metabolically programmed by auxins.
    Planta, 2014. 239(4): p. 765-81
    [PMID:24370633]
  4. Ranocha P,Francoz E,Burlat V,Dunand C
    Expression of PRX36, PMEI6 and SBT1.7 is controlled by complex transcription factor regulatory networks for proper seed coat mucilage extrusion.
    Plant Signal Behav, 2014. 9(11): p. e977734
    [PMID:25531128]
  5. Zhu Z, et al.
    Characterization of the cis elements in the proximal promoter regions of the anthocyanin pathway genes reveals a common regulatory logic that governs pathway regulation.
    J. Exp. Bot., 2015. 66(13): p. 3775-89
    [PMID:25911741]
  6. Zhu Q, et al.
    Ectopic Expression of the Coleus R2R3 MYB-Type Proanthocyanidin Regulator Gene SsMYB3 Alters the Flower Color in Transgenic Tobacco.
    PLoS ONE, 2015. 10(10): p. e0139392
    [PMID:26448466]
  7. Li P, et al.
    Regulation of anthocyanin and proanthocyanidin biosynthesis by Medicago truncatula bHLH transcription factor MtTT8.
    New Phytol., 2016. 210(3): p. 905-21
    [PMID:26725247]
  8. Bulgakov VP,Veremeichik GN,Grigorchuk VP,Rybin VG,Shkryl YN
    The rolB gene activates secondary metabolism in Arabidopsis calli via selective activation of genes encoding MYB and bHLH transcription factors.
    Plant Physiol. Biochem., 2016. 102: p. 70-9
    [PMID:26913794]
  9. Petridis A,Döll S,Nichelmann L,Bilger W,Mock HP
    Arabidopsis thaliana G2-LIKE FLAVONOID REGULATOR and BRASSINOSTEROID ENHANCED EXPRESSION1 are low-temperature regulators of flavonoid accumulation.
    New Phytol., 2016. 211(3): p. 912-25
    [PMID:27125220]
  10. Rai A, et al.
    Coordinate Regulation of Metabolite Glycosylation and Stress Hormone Biosynthesis by TT8 in Arabidopsis.
    Plant Physiol., 2016. 171(4): p. 2499-515
    [PMID:27432888]
  11. Li Y, et al.
    Two IIIf Clade-bHLHs from Freesia hybrida Play Divergent Roles in Flavonoid Biosynthesis and Trichome Formation when Ectopically Expressed in Arabidopsis.
    Sci Rep, 2016. 6: p. 30514
    [PMID:27465838]
  12. Mahmood K,Xu Z,El-Kereamy A,Casaretto JA,Rothstein SJ
    The Arabidopsis Transcription Factor ANAC032 Represses Anthocyanin Biosynthesis in Response to High Sucrose and Oxidative and Abiotic Stresses.
    Front Plant Sci, 2016. 7: p. 1548
    [PMID:27790239]
  13. Zou B, et al.
    Calmodulin-binding protein CBP60g functions as a negative regulator in Arabidopsis anthocyanin accumulation.
    PLoS ONE, 2017. 12(3): p. e0173129
    [PMID:28253311]
  14. Chen K,Liu H,Lou Q,Liu Y
    Ectopic Expression of the Grape Hyacinth (Muscari armeniacum) R2R3-MYB Transcription Factor Gene, MaAN2, Induces Anthocyanin Accumulation in Tobacco.
    Front Plant Sci, 2017. 8: p. 965
    [PMID:28642775]
  15. Kataya ARA, et al.
    PLATINUM SENSITIVE 2 LIKE impacts growth, root morphology, seed set, and stress responses.
    PLoS ONE, 2017. 12(7): p. e0180478
    [PMID:28678890]
  16. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]
  17. Feng K, et al.
    An R2R3-MYB transcription factor, OjMYB1, functions in anthocyanin biosynthesis in Oenanthe javanica.
    Planta, 2018. 247(2): p. 301-315
    [PMID:28965159]
  18. Wen J, et al.
    The C-terminal domains of Arabidopsis GL3/EGL3/TT8 interact with JAZ proteins and mediate dimeric interactions.
    Plant Signal Behav, 2018. 13(1): p. e1422460
    [PMID:29293407]