PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Tp3g21660
Organism
Thellungiella parvula
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassicaceae incertae sedis; Schrenkiella
Family bHLH
Protein Properties Length: 367aa    MW: 41610.3 Da    PI: 7.0752
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Tp3g21660genomethellungiellaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH35.32e-11155206155
                CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
        HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                +r ah ++Er+RR+++N+ +  Lr+l+P +   + k+ + a+i   ++e++k+L+
  Tp3g21660 155 QRLAHIMVERNRRKQMNEHLRVLRSLMPGS---YVKRGDQASIIGGVIEFVKELE 206
                799***************************...9******************995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.101.2E-12153209IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000837.58E-12153210No hitNo description
SuperFamilySSF474596.54E-16154219IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088814.843154205IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000109.5E-9155206IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003537.9E-9160211IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd048730.00189293357No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 367 aa     Download sequence    Send to blast
MQQHKQSMPQ QQQLSPSGFG ATPTFDKMSF ADVMHFADLG PELVLNRTRN QDVQETGIDP  60
VYFLKFPVLN ERIEDYNQTQ HFMSSYRTPQ EGGECGGNIG SVFLEDKEKN SVQLRFIGGE  120
QKEEDRENKN VTTKEVKSKR KRATTSKTIE EVESQRLAHI MVERNRRKQM NEHLRVLRSL  180
MPGSYVKRGD QASIIGGVIE FVKELEQLLQ CLESQKRRRI LGETGHRQIG DMTTPMSSSS  240
SPITVVANNQ PQRHIITGNV TELEGGGGLL EETAENKSFL ADVEVKLLGF EAMIKILSRR  300
RPGQLIKTIA ALEDLHLSIL HTNITTMEQT VLYSFNVKIT CERRVTAEDI ASSIQQIFSF  360
IHENTTM
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1215219KRRRI
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapTp3g21660
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_002883481.20.0transcription factor FAMA
SwissprotQ56YJ80.0FAMA_ARATH; Transcription factor FAMA
TrEMBLD7L4810.0D7L481_ARALL; Uncharacterized protein
STRINGscaffold_302925.10.0(Arabidopsis lyrata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM55482649
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-162bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]