PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

XP_010557436.1

Organism

Tarenaya hassleriana

Taxonomic ID

28532

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Cleomaceae; Tarenaya

Family

E2F/DP

Protein Properties

Length: 416aa MW: 45892.3 Da PI: 4.5767

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_010557436.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	84.2	1e-26	112	177	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+g+++ln++a+ L +v ++RRiYDi+NVLe+++liekk kn+i+wkg XP_010557436.1 112 RYDSSLGLLTKKFIALIQQAEDGVLDLNKAASIL---EV--QKRRIYDITNVLEGVGLIEKKLKNRIQWKG 177 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.5E-28	110	178	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	1.09E-16	112	175	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.3E-34	112	177	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	5.6E-24	114	177	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.53E-45	188	294	No hit	No description
SuperFamily	SSF144074	3.4E-32	189	294	No hit	No description
Pfam	PF16421	8.4E-32	193	292	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 416 aa Download sequence Send to blast
MKPPILSPGD LHRFSSASTN QGADREGDSV VAKSTSKRKS DGTDHEAETR DSINVPGYSE 60 AVLTSVQTPL GAKGKAQKTS RSARSKQNGP STPGSNLSSP GGTNNAFGAA CRYDSSLGLL 120 TKKFIALIQQ AEDGVLDLNK AASILEVQKR RIYDITNVLE GVGLIEKKLK NRIQWKGLGV 180 LGPGEAIENV ARLQTELQDL TGEERQLDEQ IRAMQERLRG FSEEEENRKW LFITEEDIKS 240 LPCLQNETLI AIKAPHGTTL EVPDPDEAVD YPLRRYRMVL RSTMGPIDVY LVSQFEEKFE 300 EIHREEAMPK VPSSSVLTAE MENAEEGEQK DQRTRSSADP SRDLSTGITK IIPDDFDADA 360 DYWLLSDASL GVSITELWQI EPDMQWTELG PLCEEYAIPR PESPLFNPKA ATSTSG

Sequence ? help Back to Top

Protein Sequence Length: 416 aa Download sequence Send to blast

MKPPILSPGD LHRFSSASTN QGADREGDSV VAKSTSKRKS DGTDHEAETR DSINVPGYSE  60
AVLTSVQTPL GAKGKAQKTS RSARSKQNGP STPGSNLSSP GGTNNAFGAA CRYDSSLGLL  120
TKKFIALIQQ AEDGVLDLNK AASILEVQKR RIYDITNVLE GVGLIEKKLK NRIQWKGLGV  180
LGPGEAIENV ARLQTELQDL TGEERQLDEQ IRAMQERLRG FSEEEENRKW LFITEEDIKS  240
LPCLQNETLI AIKAPHGTTL EVPDPDEAVD YPLRRYRMVL RSTMGPIDVY LVSQFEEKFE  300
EIHREEAMPK VPSSSVLTAE MENAEEGEQK DQRTRSSADP SRDLSTGITK IIPDDFDADA  360
DYWLLSDASL GVSITELWQI EPDMQWTELG PLCEEYAIPR PESPLFNPKA ATSTSG

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	6e-26	108	179	3	75	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_010557436.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010557436.1	0.0	PREDICTED: transcription factor E2FB-like isoform X2
Swissprot	Q9FV71	1e-136	E2FB_ARATH; Transcription factor E2FB
TrEMBL	V4RS35	1e-172	V4RS35_9ROSI; Uncharacterized protein
STRING	XP_010557435.1	0.0	(Tarenaya hassleriana)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	1e-134	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]