PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Thecc1EG022853t1
Common NameTCM_022853
Organism
Theobroma cacao
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma
Family E2F/DP
Protein Properties Length: 481aa    MW: 52637.6 Da    PI: 5.0639
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Thecc1EG022853t1genomeCGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.58.1e-27172237171
           E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                       r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Thecc1EG022853t1 172 RYDSSLGLLTKKFINLIKHAEDGMLDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIHWKG 237
                       6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.105.2E-29169239IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.3E-34172237IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467855.53E-17172235IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023193.6E-24174237IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440742.01E-33250354No hitNo description
CDDcd146606.88E-49250354No hitNo description
PfamPF164212.8E-33253352IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 481 aa     Download sequence    Send to blast
MSGGARASAR PRPPHPPPPP SAVSSPASAG PSIVPPIRRH LAFASTKPPF VHPDDYHRFS  60
SNNNNNYPNN SLTSASNARG AVADQEVEAI VVRSPQFKRK STVNKNEVES SHWTTSPGVS  120
SISNSLFQTP VSAKGGRLNN RSKASKANKS TPQTPMSNAG SLSPLTPAGS CRYDSSLGLL  180
TKKFINLIKH AEDGMLDLNK AAETLEVQKR RIYDITNVLE GIGLIEKKLK NRIHWKGVDA  240
SRPGEADGDV SILQAEIENL SIEENRLDDQ IREMQERLRD LSENENNQRW LFVTEEDIKG  300
IPCFQNETLI AIKAPHGTTL EVPDPDEAVD YSQRRYRIIL RSTMGPVDVY LVSQFEEKFE  360
ELNGVEPPVR LPLASSSGSN ENQVELVNVD STRKEVEPQA QTHQMGSDIN ASQESVGGMM  420
RIVPLDIDND ADYWLLSDAD VSITDMWKTD SGVEWSGVDA LHADFGMADV STPSPQTPAI  480
*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-24167238274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017977856.10.0PREDICTED: LOW QUALITY PROTEIN: transcription factor E2FA
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A061EUU10.0A0A061EUU1_THECC; E2F transcription factor 3 isoform 1
STRINGEOY084280.0(Theobroma cacao)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]
  2. Motamayor JC, et al.
    The genome sequence of the most widely cultivated cacao type and its use to identify candidate genes regulating pod color.
    Genome Biol., 2013. 14(6): p. r53
    [PMID:23731509]