PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Thecc1EG005653t1

Common Name

TCM_005653

Organism

Theobroma cacao

Taxonomic ID

3641

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma

Family

MYB

Protein Properties

Length: 314aa MW: 35491 Da PI: 6.5328

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Thecc1EG005653t1	genome	CGD	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	42.6	1.4e-13	13	58	1	46
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46 +g+W +eEde l+ vk++G+++W++I ++ + Rt+k+c++rw + Thecc1EG005653t1 13 KGPWKAEEDEVLISHVKKYGPRDWSSIRSKGLLQRTGKSCRLRWVN 58 79***********************8887799********87 PP
2	Myb_DNA-binding	44.7	3.2e-14	69	108	3	44
SS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHH CS Myb_DNA-binding 3 rWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrw 44 ++T+eE+ +++ q+G++ W++Ia +++ gRt++++k++w Thecc1EG005653t1 69 KFTAEEERVVIELQSQFGNK-WAKIATYLP-GRTDNDVKNFW 108 79****************.*****.********* PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.60	2.4E-21	8	61	IPR009057	Homeodomain-like
PROSITE profile	PS51294	20.917	8	64	IPR017930	Myb domain
SuperFamily	SSF46689	9.36E-29	11	108	IPR009057	Homeodomain-like
SMART	SM00717	7.6E-11	12	62	IPR001005	SANT/Myb domain
CDD	cd00167	1.25E-11	15	60	No hit	No description
Pfam	PF13921	3.6E-12	16	66	No hit	No description
Gene3D	G3DSA:1.10.10.60	1.3E-18	62	114	IPR009057	Homeodomain-like
PROSITE profile	PS51294	19.017	65	116	IPR017930	Myb domain
SMART	SM00717	9.7E-13	66	114	IPR001005	SANT/Myb domain
Pfam	PF00249	2.4E-12	69	108	IPR001005	SANT/Myb domain
CDD	cd00167	3.69E-11	69	108	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0048235	Biological Process	pollen sperm cell differentiation
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 314 aa Download sequence Send to blast
MEGKRVEMSQ IRKGPWKAEE DEVLISHVKK YGPRDWSSIR SKGLLQRTGK SCRLRWVNKL 60 RPNLKNGCKF TAEEERVVIE LQSQFGNKWA KIATYLPGRT DNDVKNFWSS RQKRLARILQ 120 NSGTPSSYSK SPKIKKEVPV FHNVPALEAP KFSSSMEEAS YSKGQSCSSS YIDNSETTKL 180 EQLPDLVNPK LYNIDANGAQ LELMSRGQNP YAEAQPQFFF PQIPQPQPYL TLSLESQDLL 240 AKFEDPYFSQ VFAPMDVPEL GSGHVGQPFL EPVRCSGFGA REETDNPVTP DTFFDDFPAD 300 MFDHMEPLPS PSE*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1h8a_C	2e-29	10	114	24	126	MYB TRANSFORMING PROTEIN
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that acts as a positive regulator of male germline development by promoting both gametic cell specification and cell cycle progression (PubMed:15694308, PubMed:15618418, PubMed:19300502, PubMed:21285328). Binds to canonical MYB sites 5'-AACCGTC-3', 5'-AAACCGC-3' and 5'-AACCGT-3' in promoters to trigger the expression of male germline-specific or enriched genes (e.g. MGH3, GEX2 and GCS1), including those required for fertilization (PubMed:21285328, PubMed:19300502). Required for sperm cell specification leading to pollen maturation by activating a germline-specific regulon (PubMed:21285328, PubMed:15694308, PubMed:15618418, PubMed:19300502). Involved in pollen mitosis entry at G2-M transition via the regulation of CYCB1-1, DAZ1 and DAZ2 expression (PubMed:15618418, PubMed:19300502, PubMed:24876252). {ECO:0000269\|PubMed:15618418, ECO:0000269\|PubMed:15694308, ECO:0000269\|PubMed:19300502, ECO:0000269\|PubMed:21285328, ECO:0000269\|PubMed:24876252}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Repressed by the microRNA 159 (miR159); the production of miR159 is stimulated by the anaphase promoting complex/cyclosome (APC/C) (PubMed:21441434). Activated by ARID1 in male germline cells via specific histone acetylation regulation (e.g. H3K9Ac) (PubMed:25057814). {ECO:0000269\|PubMed:21441434, ECO:0000269\|PubMed:25057814}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_007052245.1	0.0	PREDICTED: transcription factor MYB59
Swissprot	A0A178VEK7	8e-89	DUO1_ARATH; Transcription factor DUO1
TrEMBL	A0A061DVG4	0.0	A0A061DVG4_THECC; Myb-like HTH transcriptional regulator family protein, putative
STRING	EOX96402	0.0	(Theobroma cacao)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM6551	28	42

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G60460.1	1e-76	MYB family protein

Link Out ? help Back to Top
Phytozome	Thecc1EG005653t1
Entrez Gene	18614424

Publications ? help Back to Top
Motamayor JC, et al. The genome sequence of the most widely cultivated cacao type and its use to identify candidate genes regulating pod color. Genome Biol., 2013. 14(6): p. r53 [PMID:23731509] Zheng B,He H,Zheng Y,Wu W,McCormick S An ARID domain-containing protein within nuclear bodies is required for sperm cell formation in Arabidopsis thaliana. PLoS Genet., 2014. 10(7): p. e1004421 [PMID:25057814] Peters B, et al. A Conserved cis-Regulatory Module Determines Germline Fate through Activation of the Transcription Factor DUO1 Promoter. Plant Physiol., 2017. 173(1): p. 280-293 [PMID:27624837] Zheng Z, et al. Target RNA Secondary Structure Is a Major Determinant of miR159 Efficacy. Plant Physiol., 2017. 174(3): p. 1764-1778 [PMID:28515145]