PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PGSC0003DMP400028726
Organism
Solanum tuberosum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
Family E2F/DP
Protein Properties Length: 473aa    MW: 51937.8 Da    PI: 4.6901
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PGSC0003DMP400028726genomePGSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP80.91.1e-25152215171
               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                           r+++sL+llt+kf++l++++e+g+++ln++a++L       ++RRiYDi+NVLe+++liekk kn+i+wkg
  PGSC0003DMP400028726 152 RYDSSLGLLTKKFINLIKHAEDGMLDLNQAADTL-------EKRRIYDITNVLEGIGLIEKKLKNRIQWKG 215
                           6899******************************.......89**************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.105.6E-27150217IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.54E-15152213IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.9E-31152215IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.7E-22154215IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146607.77E-48226332No hitNo description
SuperFamilySSF1440741.6E-33229332No hitNo description
PfamPF164211.9E-33231330IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 473 aa     Download sequence    Send to blast
MTGSSASTGA AAPPTAQSSS AAVNGGGRSQ ISHPIKRYLP FASMRPPFVT PEDYHRFSIP  60
GVDSRIGSAS LQPEAIVALK RKTGYIKEVE SSDWTANSGY ADVANSPLGT PVSGKGGRAH  120
GRSRATKNNK SGPQTPVYNA GSPSPLTPAS CRYDSSLGLL TKKFINLIKH AEDGMLDLNQ  180
AADTLEKRRI YDITNVLEGI GLIEKKLKNR IQWKGVDSSR PGEVDNDASI LKAETDRLSM  240
EERRLDERIR EMQEKLRDMS EDENNQRWLF VTEEDIKSLP CFQNETLIAV KAPHGTTLEV  300
PDPDEAVDYP QRRYRIILRS TMGPIDVYLV SQFEEKFEEM NGVEPPTTIP VASSSGSKDY  360
PTMEISTVSN SVTENEEQTH NVDHLSSDLG TSQDYNGGMM KILPSDVDND SDYWLLSDAN  420
VSITDMWKTD STVEWDGETL LRDFGIDDLG TPRAHTPSTI ADVPDPMNVP PR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-24145216274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00661PBMTransfer from Pp3c1_6880Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapPGSC0003DMP400028726
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC2397381e-114AC239738.5 Solanum lycopersicum strain Heinz 1706 chromosome 1 clone hba-240p19 map 1, complete sequence.
GenBankHG9754401e-114HG975440.1 Solanum pennellii chromosome ch01, complete genome.
GenBankHG9755131e-114HG975513.1 Solanum lycopersicum chromosome ch01, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006348487.10.0PREDICTED: transcription factor E2FA isoform X2
SwissprotQ9FNY01e-155E2FA_ARATH; Transcription factor E2FA
TrEMBLM1BCW00.0M1BCW0_SOLTU; Uncharacterized protein
STRINGPGSC0003DMT4000423470.0(Solanum tuberosum)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-159E2F transcription factor 3
Publications ? help Back to Top
  1. Xu X, et al.
    Genome sequence and analysis of the tuber crop potato.
    Nature, 2011. 475(7355): p. 189-95
    [PMID:21743474]
  2. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]