PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Sp_042010_qucd.t1

Common Name

SOVF_042010

Organism

Spinacia oleracea

Taxonomic ID

3562

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Caryophyllales; Chenopodiaceae; Chenopodioideae; Anserineae; Spinacia

Family

NAC

Protein Properties

Length: 430aa MW: 48163.4 Da PI: 5.054

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Sp_042010_qucd.t1	genome	TBVR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	104.9	1e-32	55	193	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkk.....leleevikevd....iykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratk.... 79 lp+G++F+Ptd+e+ ++ L+k+ g++ + +e+i++vd i++++P++Lp vk + + +fF+++ k+y+tg+rk+r+++ Sp_042010_qucd.t1 55 LPRGVKFDPTDQEITQHLLAKSGIGDEaphpfI--DEFIPTVDeddgICYTHPENLP-GVKRDGSASHFFHRAIKAYNTGTRKRRKIHgnnl 143 799**********999988866666675432..334666644556******.677888999**************8654555 PP NAM 80 .sgyWkatgkdkevlskkgelvglkktLvfy.kgrapkgektdWvmheyrl 128 + +W++tg++k+vl +ge++g+kk++v+y + k+ekt+Wvmh+y+l Sp_042010_qucd.t1 144 gDVRWHKTGRTKPVLL-NGEQKGCKKIMVLYvAVKGGKPEKTNWVMHQYHL 193 5889********.999*******644777778*******98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	1.57E-37	40	212	IPR003441	NAC domain
PROSITE profile	PS51005	30.993	55	212	IPR003441	NAC domain
Pfam	PF02365	6.3E-14	56	193	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000077	Biological Process	DNA damage checkpoint
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010332	Biological Process	response to gamma radiation
GO:0040020	Biological Process	regulation of meiotic nuclear division
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 430 aa Download sequence Send to blast
RSWLVDGNRF ATKIKCASGS CDLGNIKWKS NPTRSCPNCH HTIDNNDVGQ EWPGLPRGVK 60 FDPTDQEITQ HLLAKSGIGD EAPHPFIDEF IPTVDEDDGI CYTHPENLPG VKRDGSASHF 120 FHRAIKAYNT GTRKRRKIHG NNLGDVRWHK TGRTKPVLLN GEQKGCKKIM VLYVAVKGGK 180 PEKTNWVMHQ YHLGIEEDEK DGSHVISKVF YQQQQLVKQS EKTTGYISDV AEDSVVKVDP 240 VTPKSVTPDP PRNEMRLHTK NDISSVNCNS GAQDREMGFA DEVQQEITIS SGVNDSIKDD 300 CIDITSQDPV LEHGDNTVEE EKWWDSESQY LLNSQQLVEG LSLCDELLQS QSPNRNGSTN 360 TDDVAKKRYV LSEYARLGPD DLKKDLEDCQ NLVLDPANID LDTPPDFRLS QLEFGSQDSY 420 SAWGLGKTTD

Sequence ? help Back to Top

Protein Sequence Length: 430 aa Download sequence Send to blast

RSWLVDGNRF ATKIKCASGS CDLGNIKWKS NPTRSCPNCH HTIDNNDVGQ EWPGLPRGVK  60
FDPTDQEITQ HLLAKSGIGD EAPHPFIDEF IPTVDEDDGI CYTHPENLPG VKRDGSASHF  120
FHRAIKAYNT GTRKRRKIHG NNLGDVRWHK TGRTKPVLLN GEQKGCKKIM VLYVAVKGGK  180
PEKTNWVMHQ YHLGIEEDEK DGSHVISKVF YQQQQLVKQS EKTTGYISDV AEDSVVKVDP  240
VTPKSVTPDP PRNEMRLHTK NDISSVNCNS GAQDREMGFA DEVQQEITIS SGVNDSIKDD  300
CIDITSQDPV LEHGDNTVEE EKWWDSESQY LLNSQQLVEG LSLCDELLQS QSPNRNGSTN  360
TDDVAKKRYV LSEYARLGPD DLKKDLEDCQ NLVLDPANID LDTPPDFRLS QLEFGSQDSY  420
SAWGLGKTTD

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
3ulx_A	5e-13	55	193	15	140	Stress-induced transcription factor NAC1
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269\|PubMed:19549833, ECO:0000269\|PubMed:20634150, ECO:0000269\|PubMed:24399300, ECO:0000305\|PubMed:24736489}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269\|PubMed:23907539}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_021850014.1	0.0	SUPPRESSOR OF GAMMA RESPONSE 1
Swissprot	Q6NQK2	1e-173	NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBL	A0A0K9RQ22	0.0	A0A0K9RQ22_SPIOL; Uncharacterized protein (Fragment)
STRING	XP_010695823.1	0.0	(Beta vulgaris)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G25580.1	1e-175	NAC family protein

Publications ? help Back to Top
Yi D, et al. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. Plant Cell, 2014. 26(1): p. 296-309 [PMID:24399300] Biever JJ,Brinkman D,Gardner G UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation. J. Exp. Bot., 2014. 65(11): p. 2949-61 [PMID:24591052] Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell, 2015. 27(1): p. 149-61 [PMID:25595823] Chen P,Umeda M DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana. Genes Cells, 2015. 20(8): p. 636-46 [PMID:26033196] Sjogren CA,Bolaris SC,Larsen PB Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response. Plant Cell, 2015. 27(9): p. 2501-15 [PMID:26320227] Yoshiyama KO SOG1: a master regulator of the DNA damage response in plants. Genes Genet. Syst., 2016. 90(4): p. 209-16 [PMID:26617076] Weimer AK, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J., 2016. 35(19): p. 2068-2086 [PMID:27497297] Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana. Genes Cells, 2016. 21(11): p. 1195-1208 [PMID:27658920] Pedroza-García JA, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol., 2017. 173(3): p. 1735-1749 [PMID:28153919] Horvath BM, et al. Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control. EMBO J., 2017. 36(9): p. 1261-1278 [PMID:28320736] Sjogren CA,Larsen PB SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Plant Cell Environ., 2017. 40(9): p. 1849-1860 [PMID:28556304] Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana. Plant Cell, 2017. 29(12): p. 3255-3268 [PMID:29208704] Johnson RA, et al. SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration. Plant Physiol., 2018. 176(2): p. 1665-1675 [PMID:29222192] Ogita N, et al. Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Plant J., 2018. 94(3): p. 439-453 [PMID:29430765] Cao X, et al. Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots. Chemosphere, 2018. 201: p. 586-594 [PMID:29533809]