PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

131087

Organism

Selaginella moellendorffii

Taxonomic ID

88036

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Lycopodiidae; Selaginellales; Selaginellaceae; Selaginella

Family

bHLH

Protein Properties

Length: 175aa MW: 19603.5 Da PI: 8.8259

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
131087	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	14.3	7.7e-05	1	37	16	55
HHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 16 iNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +N+ ++ Lr+l+P + + ++ + a+i A+e++k+L+ 131087 1 MNEHLNVLRSLMPGS---YVQRGDQASIIGGAIEFVKELE 37 8************...9****************995 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF47459	1.57E-8	1	50	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	10.652	1	36	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	3.56E-6	1	41	No hit	No description
Gene3D	G3DSA:4.10.280.10	1.7E-6	1	48	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 175 aa Download sequence Send to blast
MNEHLNVLRS LMPGSYVQRG DQASIIGGAI EFVKELEQLL QCLQAQKRRR LYSDAFTADS 60 SSKFVNDNFY DCKQIVAEAK SEVADIEVRM AGSDAVVKIL SQRRPGQLLK TISALESMCM 120 SIVHTNITTI EQTVLYSFTV RVSSKFFISY VWLGLTRFSL NLSTDWHGIQ AKRG*

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	46	50	KRRRL

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269\|PubMed:17088607, ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267, ECO:0000269\|PubMed:24571519, ECO:0000269\|PubMed:24654956}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269\|PubMed:22442411}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_024519722.1	1e-92	transcription factor SPEECHLESS
Refseq	XP_024519723.1	1e-92	transcription factor SPEECHLESS
Refseq	XP_024519724.1	1e-92	transcription factor SPEECHLESS
Refseq	XP_024519725.1	1e-92	transcription factor SPEECHLESS
Refseq	XP_024519726.1	1e-92	transcription factor SPEECHLESS
Refseq	XP_024521953.1	1e-92	transcription factor SPEECHLESS
Refseq	XP_024521954.1	1e-92	transcription factor SPEECHLESS
Refseq	XP_024521956.1	1e-92	transcription factor SPEECHLESS
Refseq	XP_024521957.1	1e-92	transcription factor SPEECHLESS
Refseq	XP_024521958.1	1e-92	transcription factor SPEECHLESS
Swissprot	Q56YJ8	3e-54	FAMA_ARATH; Transcription factor FAMA
TrEMBL	D8T3L6	3e-89	D8T3L6_SELML; Uncharacterized protein FAMA1-1
TrEMBL	D8TAA2	3e-89	D8TAA2_SELML; Uncharacterized protein FAMA1-2
STRING	EFJ06465	5e-90	(Selaginella moellendorffii)
STRING	EFJ08722	6e-90	(Selaginella moellendorffii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Representative plant	OGRP253	15	131

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G24140.1	1e-46	bHLH family protein

Link Out ? help Back to Top
Phytozome	131087

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Matos JL, et al. Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] Chen L, et al. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] Li X,Yang R,Chen H The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]