PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00015261-RA_Salv
Organism
Salvia miltiorrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family E2F/DP
Protein Properties Length: 376aa    MW: 42318.9 Da    PI: 8.6604
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00015261-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.44.9e-232792171
                E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                           rk+ksL+ll+++fl+l+ +   + + l+++a++L    v  +rRRiYDi+NVLe+++++ +k+kn+++wkg
  SMil_00015261-RA_Salv 27 RKQKSLGLLCSNFLSLYDHDGVESIGLDDAASKL---GV--ERRRIYDIVNVLESVGILMRKAKNRYTWKG 92
                           79*****************999************...**..****************************98 PP
2E2F_TDP75.84.2e-24155236171
                E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse......dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                            rkeksL+lltq+f+kl+ +++ ++++l+++ak L+ +       +++k+RR+YDi+NVL++++ iek     ++k+++rw g
  SMil_00015261-RA_Salv 155 RKEKSLGLLTQNFVKLFLCTDMDMISLDDAAKLLLGDgkhtsmTTRTKVRRLYDIANVLSSMKFIEKthhpeTRKPAFRWLG 236
                            79*****************************************999**********************99999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.106.5E-262593IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.5E-272792IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.18E-152790IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023197.6E-202892IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.0E-23151237IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.5E-31155236IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.5E-18156236IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.09E-12157237IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 376 aa     Download sequence    Send to blast
LKRAMALLST HAGAVTESGS KDIPYCRKQK SLGLLCSNFL SLYDHDGVES IGLDDAASKL  60
GVERRRIYDI VNVLESVGIL MRKAKNRYTW KGFGAIPKAL EDLKREGLRD IVPAADTSCS  120
EKISDDEEDE MCSDMNSLSQ NDRSDSSSVF KRDSRKEKSL GLLTQNFVKL FLCTDMDMIS  180
LDDAAKLLLG DGKHTSMTTR TKVRRLYDIA NVLSSMKFIE KTHHPETRKP AFRWLGLTGK  240
PDNRTDDSLI LSDSKKRIFG TDLTNATTKR LRMDEERFKI LKAHNQVQVK HEKENEDERV  300
TAGKSYQFGP FAPANVPKVG DSHDGKGKDV DWESLASSYR PQYHNQALKD LFSHFVEAWK  360
SWYSEVAGKG PIQLGS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-35272284228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011071778.10.0E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-117E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A4D9C2N70.0A0A4D9C2N7_SALSN; Transcription factor E2F7/8
STRINGMigut.I00063.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-106DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]