PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00007808-RA_Salv
Organism
Salvia miltiorrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family E2F/DP
Protein Properties Length: 343aa    MW: 38817.8 Da    PI: 8.8565
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00007808-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.72e-232186171
                E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                           rkeksL+ll+++fl+l+ ++  + + l+ +a +L    v  +rRRiYDi+N+Le++++++kkekn+++wkg
  SMil_00007808-RA_Salv 21 RKEKSLGLLCTNFLRLYDREGVDSIGLDAAALQL---GV--ERRRIYDIVNILEGIGVLQKKEKNQYTWKG 86
                           79*****************999************...**..****************************98 PP
2E2F_TDP71.68.8e-23142221170
                E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwk 70 
                            r+eksL+lltq+f+kl+ +se +i++l+ +a +L+ +      +++k+RR+YDi+NV+++++liek     + k+++rw 
  SMil_00007808-RA_Salv 142 RREKSLGLLTQNFVKLFLCSEVEIISLDGAALALLGDshdrtAMRTKVRRLYDIANVFSSMGLIEKvrdpeSGKPAFRWT 221
                            689***************************************************************9999999*****96 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.8E-251987IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.71E-152184IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.6E-262186IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.1E-202286IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.106.6E-21138222IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-28142222IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467858.84E-11144221IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.3E-17144221IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 343 aa     Download sequence    Send to blast
LKSVAVMASR DSRTKDAFYC RKEKSLGLLC TNFLRLYDRE GVDSIGLDAA ALQLGVERRR  60
IYDIVNILEG IGVLQKKEKN QYTWKGFAAI SGALEVLKEQ GEKEEFHTYI TNVSNEKERS  120
LLSDSKTECP DKCSKSDKGE HRREKSLGLL TQNFVKLFLC SEVEIISLDG AALALLGDSH  180
DRTAMRTKVR RLYDIANVFS SMGLIEKVRD PESGKPAFRW TSVGRSRNRS SIASDGKNCK  240
RRAFGDDITN TSVKKCKTIA LTEQHQKYSS KDFVFGPFAP NVSMVESHET SKDGQIQNWD  300
NLFCAHRPQY SNKAVGDLFH HYAEAWSNWR DEAKDKQQIE HGS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A6e-37212084222Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020554916.11e-163E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ42e-94E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A4D9B2060.0A0A4D9B206_SALSN; Uncharacterized protein
STRINGMigut.H00175.1.p1e-161(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.22e-89DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]