PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00000278-RA_Salv
Common NameMYB96
Organism
Salvia miltiorrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family MYB
Protein Properties Length: 285aa    MW: 32171.4 Da    PI: 6.5215
Description MYB family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00000278-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding43.19.7e-141964146
                           TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS
        Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46
                           +g+W  eEde l++ vk++G+++W++I ++  ++Rt+k+c++rw +
  SMil_00000278-RA_Salv 19 KGPWKVEEDEVLINHVKKYGPRDWSSIRSKGLLRRTGKSCRLRWVN 64
                           79*************************888779***********87 PP
2Myb_DNA-binding43.29.2e-1474114244
                            SSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHH CS
        Myb_DNA-binding   2 grWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrw 44 
                            ++++++E+   +d+ +q+G++ W++Ia +++ gRt++++k++w
  SMil_00000278-RA_Salv  74 MKFSADEERTVIDLQAQFGNK-WAKIATYLQ-GRTDNDVKNFW 114
                            589******************.*********.*********** PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5129422.0291470IPR017930Myb domain
Gene3DG3DSA:1.10.10.601.0E-201667IPR009057Homeodomain-like
SuperFamilySSF466891.64E-2716114IPR009057Homeodomain-like
SMARTSM007175.1E-121868IPR001005SANT/Myb domain
CDDcd001671.27E-122166No hitNo description
PfamPF139219.6E-122272No hitNo description
Gene3DG3DSA:1.10.10.602.5E-1768120IPR009057Homeodomain-like
PROSITE profilePS5129415.68871122IPR017930Myb domain
SMARTSM007171.7E-1072120IPR001005SANT/Myb domain
PfamPF002494.4E-1274114IPR001005SANT/Myb domain
CDDcd001675.48E-1075114No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0048235Biological Processpollen sperm cell differentiation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 285 aa     Download sequence    Send to blast
MMEGKRRMAH DDELRDIKKG PWKVEEDEVL INHVKKYGPR DWSSIRSKGL LRRTGKSCRL  60
RWVNKLRPDL KTGMKFSADE ERTVIDLQAQ FGNKWAKIAT YLQGRTDNDV KNFWSSRQKR  120
LARILHTSTA PSSSKSHKTT KHLQTPPFDF IPSLKATKLE EEFAASSMET VPFGEVVYPS  180
PISAVPVEQQ PYVAFPQFPM LPPDYPPLLE GQDFIGRLGA PNFLDDELGH SALGTAQVPI  240
APSFQASGTS ESHDAVDIDS LMDDDFPPID LFDQIEPLPS PSHWS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1h8a_C5e-261612024126MYB TRANSFORMING PROTEIN
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that acts as a positive regulator of male germline development by promoting both gametic cell specification and cell cycle progression (PubMed:15694308, PubMed:15618418, PubMed:19300502, PubMed:21285328). Binds to canonical MYB sites 5'-AACCGTC-3', 5'-AAACCGC-3' and 5'-AACCGT-3' in promoters to trigger the expression of male germline-specific or enriched genes (e.g. MGH3, GEX2 and GCS1), including those required for fertilization (PubMed:21285328, PubMed:19300502). Required for sperm cell specification leading to pollen maturation by activating a germline-specific regulon (PubMed:21285328, PubMed:15694308, PubMed:15618418, PubMed:19300502). Involved in pollen mitosis entry at G2-M transition via the regulation of CYCB1-1, DAZ1 and DAZ2 expression (PubMed:15618418, PubMed:19300502, PubMed:24876252). {ECO:0000269|PubMed:15618418, ECO:0000269|PubMed:15694308, ECO:0000269|PubMed:19300502, ECO:0000269|PubMed:21285328, ECO:0000269|PubMed:24876252}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by the microRNA 159 (miR159); the production of miR159 is stimulated by the anaphase promoting complex/cyclosome (APC/C) (PubMed:21441434). Activated by ARID1 in male germline cells via specific histone acetylation regulation (e.g. H3K9Ac) (PubMed:25057814). {ECO:0000269|PubMed:21441434, ECO:0000269|PubMed:25057814}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKF0594500.0KF059450.1 Salvia miltiorrhiza MYB-related transcription factor (MYB96) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011093325.11e-111transcription factor MYB63-like
SwissprotA0A178VEK75e-73DUO1_ARATH; Transcription factor DUO1
TrEMBLA0A059PRL20.0A0A059PRL2_SALMI; MYB-related transcription factor
STRINGXP_009630342.16e-81(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA42072342
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G60460.12e-72MYB family protein
Publications ? help Back to Top
  1. Li C,Lu S
    Genome-wide characterization and comparative analysis of R2R3-MYB transcription factors shows the complexity of MYB-associated regulatory networks in Salvia miltiorrhiza.
    BMC Genomics, 2014. 15: p. 277
    [PMID:24725266]
  2. Zheng B,He H,Zheng Y,Wu W,McCormick S
    An ARID domain-containing protein within nuclear bodies is required for sperm cell formation in Arabidopsis thaliana.
    PLoS Genet., 2014. 10(7): p. e1004421
    [PMID:25057814]
  3. Peters B, et al.
    A Conserved cis-Regulatory Module Determines Germline Fate through Activation of the Transcription Factor DUO1 Promoter.
    Plant Physiol., 2017. 173(1): p. 280-293
    [PMID:27624837]
  4. Zheng Z, et al.
    Target RNA Secondary Structure Is a Major Determinant of miR159 Efficacy.
    Plant Physiol., 2017. 174(3): p. 1764-1778
    [PMID:28515145]