PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Sme2.5_03773.1_g00007.1
Organism
Solanum melongena
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
Family E2F/DP
Protein Properties Length: 497aa    MW: 54193.2 Da    PI: 4.5484
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Sme2.5_03773.1_g00007.1genomeEGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.71.7e-27175240171
                  E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                              r+++sL+llt+kf++l+e++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Sme2.5_03773.1_g00007.1 175 RYDSSLGLLTKKFINLIEHAEDGMLDLNQAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 240
                              6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.5E-29173242IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.22E-17175238IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.7E-34175240IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.3E-24177240IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440743.66E-34254357No hitNo description
PfamPF164212.4E-34256355IPR032198E2F transcription factor, CC-MB domain
CDDcd146603.43E-50256357No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 497 aa     Download sequence    Send to blast
MTGSGTSTGA AAPPTDQSSS AAVNGGGRSQ ISHPMKRYLP FASMRPPFVA PEDYHRFSTP  60
GVDSTIGGAS LQPEAIVVKS PHSWIGSAVL QPEASVVKST ALKRKTGYIK EVESSEWTAN  120
SGYADVVNSP LGTPVSAKGG RAHGRSRATK NNRSGPQTPV YNAGSPSPLT PASCRYDSSL  180
GLLTKKFINL IEHAEDGMLD LNQAADTLEV QKRRIYDITN VLEGIGLIEK KLKNRIQWKG  240
VDTSRPGEVD NDAAILKAEI DSLSMEERRL DERIREMQEN LRDMSEDENN QRWLFVTEED  300
IKSIPCFQNE TLIAVKAPHG TTLEVPDPDE AVDYPQRRYR IILRSTMGPI DVYLVSQFEE  360
KFEEMNGAEP STTIPVASSS GSKDYPAAEI STVSNSVTEN EGQTHNVDQL SSDLGTSQDY  420
NGGMMKILPS DVDNDADYWL LSDANVSITD MWKTDSTVEW DGETLLRDFG IDDLGTPRAQ  480
APSTIADVPA PMNVPPR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A5e-26168241274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00661PBMTransfer from Pp3c1_6880Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC2397382e-91AC239738.5 Solanum lycopersicum strain Heinz 1706 chromosome 1 clone hba-240p19 map 1, complete sequence.
GenBankHG9754402e-91HG975440.1 Solanum pennellii chromosome ch01, complete genome.
GenBankHG9755132e-91HG975513.1 Solanum lycopersicum chromosome ch01, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006348486.10.0PREDICTED: transcription factor E2FA isoform X1
SwissprotQ9FNY01e-158E2FA_ARATH; Transcription factor E2FA
TrEMBLM1BCW10.0M1BCW1_SOLTU; Uncharacterized protein
STRINGPGSC0003DMT4000423470.0(Solanum tuberosum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-162E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]