PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Sme2.5_00130.1_g00023.1
Organism
Solanum melongena
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
Family GRF
Protein Properties Length: 351aa    MW: 38617.6 Da    PI: 8.6598
Description GRF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Sme2.5_00130.1_g00023.1genomeEGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRC76.92.1e-2491135145
                      WRC   1 daepgrCrRtDGKkWRCsrrvlegkklCErHlhrgrsrsrkskee 45 
                              d+epgrCrRtDGKkWRCs+++ +++k+CErH+hrgr+rsrk++e+
  Sme2.5_00130.1_g00023.1  91 DPEPGRCRRTDGKKWRCSKDAHPDSKYCERHMHRGRNRSRKPVES 135
                              79****************************************986 PP
2QLQ65.51.3e-223065237
                      QLQ  2 aFTaaQlqlLksQilAyKyLaanqPvPpeLlqaiqk 37
                             +FTa Q+q+L++Q+++yKyL+a++PvPp+L+++i++
  Sme2.5_00130.1_g00023.1 30 PFTAVQWQELEHQAMIYKYLVAGLPVPPDLVVPIRR 65
                             9*********************************86 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM009517.9E-132965IPR014978Glutamine-Leucine-Glutamine, QLQ
PfamPF088804.3E-173064IPR014978Glutamine-Leucine-Glutamine, QLQ
PROSITE profilePS5166624.3433065IPR014978Glutamine-Leucine-Glutamine, QLQ
PROSITE profilePS5166725.83191135IPR014977WRC domain
PfamPF088796.5E-2192134IPR014977WRC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005524Molecular FunctionATP binding
Sequence ? help Back to Top
Protein Sequence    Length: 351 aa     Download sequence    Send to blast
MSGTSTASVV GVVGGGGGEV GYNDYGFRPP FTAVQWQELE HQAMIYKYLV AGLPVPPDLV  60
VPIRRSFDAI SPRFFNHPSL GYCSYYGKKF DPEPGRCRRT DGKKWRCSKD AHPDSKYCER  120
HMHRGRNRSR KPVESQTTSQ SLSTSISHIT TGSSNRSGSF QSDSSGSFQN MPLYSVANSD  180
GMSYGSTTTK LQMERASYGI NNEYRFGMTP DADDHNFLPE ASASARGVGG TGSNTDNMWR  240
LMPSQVPSKP NLKNESQLLG SSPNPFEPVI ESKQQPQHCF FSSDIGSPSA VKQEPQHPMR  300
SFFDEWPTSK ESWSNLDEGS SKNNLSTTQL SISIPNAPSG YSSRSASSPK W
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that plays a role in the regulation of meristematic function in leaves, stems and inflorescences (PubMed:24532604). Transcription activator that plays a regulatory role in grain development (PubMed:26187814, PubMed:27250747, PubMed:27250749, PubMed:26936408, PubMed:27107174). Positively regulates grain size by promoting cell division and expansion, leading to increased grain length and width (PubMed:26187814, PubMed:27250747, PubMed:27250749, PubMed:26936408, PubMed:27107174). Positively regulates the expression of genes promoting cell proliferation (PubMed:26187814, PubMed:26936408). Activates the expression of expansin genes to promote cell expansion and grain size (PubMed:27250747). May promote grain size by activating brassinosteroid responses (PubMed:27250747). Component of a network formed by the microRNA396 (miRNA396), the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation (Probable). Component of the miRNA396c-GRF4-GIF1 regulatory module that plays an important role in grain size determination (Probable) (PubMed:27250747, PubMed:27250749, PubMed:27107174). {ECO:0000269|PubMed:24532604, ECO:0000269|PubMed:26187814, ECO:0000269|PubMed:26936408, ECO:0000269|PubMed:27107174, ECO:0000269|PubMed:27250747, ECO:0000269|PubMed:27250749, ECO:0000305|PubMed:26187814, ECO:0000305|PubMed:27107174, ECO:0000305|PubMed:27250747, ECO:0000305|PubMed:27250749}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: The microRNA396c negatively regulates GRF4 at the transcriptional level. {ECO:0000269|PubMed:26187814, ECO:0000269|PubMed:26936408, ECO:0000269|PubMed:27107174, ECO:0000269|PubMed:27250747}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAP0095941e-159AP009594.1 Solanum lycopersicum DNA, chromosome 8, clone: C08HBa0022E13, complete sequence.
GenBankHG9755201e-159HG975520.1 Solanum lycopersicum chromosome ch08, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006361251.10.0PREDICTED: growth-regulating factor 4-like
RefseqXP_015170685.10.0PREDICTED: growth-regulating factor 4-like
RefseqXP_015170686.10.0PREDICTED: growth-regulating factor 4-like
SwissprotQ6ZIK51e-82GRF4_ORYSJ; Growth-regulating factor 4
TrEMBLM1BL140.0M1BL14_SOLTU; Uncharacterized protein
STRINGPGSC0003DMT4000475800.0(Solanum tuberosum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA7432384
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G13960.11e-48growth-regulating factor 5
Publications ? help Back to Top
  1. Kikuchi S, et al.
    Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice.
    Science, 2003. 301(5631): p. 376-9
    [PMID:12869764]
  2. Kuijt SJ, et al.
    Interaction between the GROWTH-REGULATING FACTOR and KNOTTED1-LIKE HOMEOBOX families of transcription factors.
    Plant Physiol., 2014. 164(4): p. 1952-66
    [PMID:24532604]
  3. Hu J, et al.
    A Rare Allele of GS2 Enhances Grain Size and Grain Yield in Rice.
    Mol Plant, 2015. 8(10): p. 1455-65
    [PMID:26187814]
  4. Sun P, et al.
    OsGRF4 controls grain shape, panicle length and seed shattering in rice.
    J Integr Plant Biol, 2016. 58(10): p. 836-847
    [PMID:26936408]
  5. Li S, et al.
    The OsmiR396c-OsGRF4-OsGIF1 regulatory module determines grain size and yield in rice.
    Plant Biotechnol. J., 2016. 14(11): p. 2134-2146
    [PMID:27107174]
  6. Che R, et al.
    Control of grain size and rice yield by GL2-mediated brassinosteroid responses.
    Nat Plants, 2015. 2: p. 15195
    [PMID:27250747]
  7. Duan P, et al.
    Regulation of OsGRF4 by OsmiR396 controls grain size and yield in rice.
    Nat Plants, 2015. 2: p. 15203
    [PMID:27250749]