PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Solyc08g005170.2.1
Common NameHSF8
Organism
Solanum lycopersicum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum; Lycopersicon
Family HSF
Protein Properties Length: 528aa    MW: 57700.8 Da    PI: 4.9661
Description HSF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Solyc08g005170.2.1genomeITAGView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HSF_DNA-bind116.81.3e-36401312102
                         HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXX CS
        HSF_DNA-bind   2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkke 92 
                         Fl k+y++++d+++++++sws ++nsfvv+d+ efak++LpkyFkh+nf+SFvRQLn+YgF+kv+ ++         weF+++ F +g+k+
  Solyc08g005170.2.1  40 FLVKTYDMVDDPSTDKIVSWSPTNNSFVVWDPPEFAKDLLPKYFKHNNFSSFVRQLNTYGFRKVDPDR---------WEFANEGFLRGQKH 121
                         9********************999*****************************************999.........************** PP

                         XXXXXXXXXX CS
        HSF_DNA-bind  93 llekikrkks 102
                         ll++i r+k 
  Solyc08g005170.2.1 122 LLKSISRRKP 131
                         *******986 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.1E-4034124IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467859.52E-3735129IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM004152.2E-6536129IPR000232Heat shock factor (HSF)-type, DNA-binding
PfamPF004471.0E-3240129IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000561.2E-204063IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000561.2E-207890IPR000232Heat shock factor (HSF)-type, DNA-binding
PROSITE patternPS00434079103IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000561.2E-2091103IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009408Biological Processresponse to heat
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 528 aa     Download sequence    Send to blast
MEPNSYGSGK AAVGDGVGAP MLQTAPAPAP IPSANAPPPF LVKTYDMVDD PSTDKIVSWS  60
PTNNSFVVWD PPEFAKDLLP KYFKHNNFSS FVRQLNTYGF RKVDPDRWEF ANEGFLRGQK  120
HLLKSISRRK PAHGHAQQQQ QPHGNAQQQM QPPGHSASVG ACVEVGKFGL EEEVERLKRD  180
KNVLMQELVR LRQQQQATDN QLQGMVQRLQ GMELRQQQMM SFLAKAVNRP GFLAQFVQQQ  240
NESNKRIAEG SKKRRIKQDI ESQDPSVTPA DGQIVKYQPG INEAAKAMLR ELSKLDSSPR  300
LDNFSNSPES FLIGDGSPQS NASSGRVSGV TLQEVPPTSG KPLLNTASAI AGQSLLPATS  360
EMQSSHLGTC SEIINNQLSN IIPLVGGEDL HPGSLSASDM IMPELSQLQG ILPENNTDVI  420
GCDSFMDTSA VEGKVGLDII GSCLSPGADI DWQSGLLDEI EEFPSVGDPF WEKFLQSPCS  480
PDAAMDDDIS NTSETKPQIN GWDKTQNMEH LTEQMGATNI KQQKHMI*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5d5u_B1e-2891294129Heat shock factor protein 1
5d5v_B1e-2891294129Heat shock factor protein 1
5d5v_D1e-2891294129Heat shock factor protein 1
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1251256KKRRIK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Les.155450.0fruit| leaf
Functional Description ? help Back to Top
Source Description
UniProtDNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. {ECO:0000250}.
Function -- GeneRIF ? help Back to Top
  1. results suggested that GmHSFA1 is a novel and functional heat-shock transcription factor. [HSFA1]
    [PMID: 16570125]
  2. In tomato, the physical interaction between the constitutively expressed HsfA1 and the heat shock (hs)-inducible HsfA2 results in synergistic transcriptional activation (superactivation) of hs gene expression.[HsfA1a]
    [PMID: 19491106]
  3. These results demonstrate that HsfA1a confers Cd tolerance by activating transcription of the COMT1 gene and inducing accumulation of melatonin that partially upregulates expression of heat-shock proteins
    [PMID: 28095626]
  4. HsfA1a role in the hydrogen peroxide production and nematode resistance.
    [PMID: 29339397]
Cis-element ? help Back to Top
SourceLink
PlantRegMapSolyc08g005170.2.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAP0115200.0Solanum lycopersicum DNA, chromosome 8, clone: C08SLe0108P16, complete sequence
GenBankX675990.0L.esculentum Le-hsf8 gene for heat stress transcription factor 8
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001296177.10.0heat shock factor protein HSF8
SwissprotQ401520.0HSF8_SOLLC; Heat shock factor protein HSF8
TrEMBLM1BII20.0M1BII2_SOLTU; Uncharacterized protein
STRINGSolyc08g005170.2.10.0(Solanum lycopersicum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA64131931
Representative plantOGRP9617233
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32330.11e-138heat shock transcription factor A1D
Publications ? help Back to Top
  1. Zhu B, et al.
    Identification and characterization of a novel heat shock transcription factor gene, GmHsfA1, in soybeans (Glycine max).
    J. Plant Res., 2006. 119(3): p. 247-56
    [PMID:16570125]
  2. Chan-Schaminet KY,Baniwal SK,Bublak D,Nover L,Scharf KD
    Specific interaction between tomato HsfA1 and HsfA2 creates hetero-oligomeric superactivator complexes for synergistic activation of heat stress gene expression.
    J. Biol. Chem., 2009. 284(31): p. 20848-57
    [PMID:19491106]
  3. Cai SY, et al.
    HsfA1a upregulates melatonin biosynthesis to confer cadmium tolerance in tomato plants.
    J. Pineal Res., 2017.
    [PMID:28095626]
  4. Zhou J, et al.
    Heat Shock Factor HsfA1a Is Essential for R Gene-Mediated Nematode Resistance and Triggers H2O2 Production1.
    Plant Physiol., 2018. 176(3): p. 2456-2471
    [PMID:29339397]