PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Seita.9G109500.1.p
Common NameKN1
Organism
Setaria italica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria
Family TALE
Protein Properties Length: 357aa    MW: 39186.1 Da    PI: 6.9232
Description TALE family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Seita.9G109500.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox26.98.1e-092843192055
                         HHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHH CS
            Homeobox  20 eknrypsaeereeLAkklgLterqVkvWFqNrRake 55 
                         +k +yps++++  LA+++gL+ +q+ +WF N+R ++
  Seita.9G109500.1.p 284 YKWPYPSETQKVALAESTGLDLKQINNWFINQRKRH 319
                         5679*****************************885 PP
2ELK37.16.6e-13239260122
                 ELK   1 ELKhqLlrKYsgyLgsLkqEFs 22 
                         ELKh+Ll+KYsgyL+sLkqE+s
  Seita.9G109500.1.p 239 ELKHHLLKKYSGYLSSLKQELS 260
                         9*******************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM012553.9E-2099143IPR005540KNOX1
PfamPF037903.1E-22100142IPR005540KNOX1
SMARTSM012561.0E-27150201IPR005541KNOX2
PfamPF037911.2E-22156199IPR005541KNOX2
SMARTSM01188570159179IPR005539ELK domain
PROSITE profilePS5121311.331239259IPR005539ELK domain
PfamPF037898.0E-10239260IPR005539ELK domain
SMARTSM011884.9E-7239260IPR005539ELK domain
PROSITE profilePS5007112.487259322IPR001356Homeobox domain
SuperFamilySSF466891.63E-19260335IPR009057Homeodomain-like
SMARTSM003894.2E-12261326IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.607.3E-28264324IPR009057Homeodomain-like
CDDcd000868.54E-12271323No hitNo description
PfamPF059206.7E-16279318IPR008422Homeobox KN domain
PROSITE patternPS000270297320IPR017970Homeobox, conserved site
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 357 aa     Download sequence    Send to blast
MEEITHHFGV GASGGHGHVQ HHLHHHHPWG SSLSAVVAPP PQTPPSAGLP LTLNTAATGN  60
SGGAGGNPVL QLANGGGLLD ACVKAKEPSS SSPYAGDVDA IKAKIISHPH YYSLLAAYLE  120
CQKVGAPPEV SARLTAMAQE LEARQRTALG GLGAATEPEL DQFMEAYHEM LVKFREELTR  180
PLQEAMEFMR RVESQLNSLS ISGRSLRNIL SSGSSEEDQE GSGGETEIPE VDAHGVDQEL  240
KHHLLKKYSG YLSSLKQELS KKKKKGKLPK EARQQLLSWW DLHYKWPYPS ETQKVALAES  300
TGLDLKQINN WFINQRKRHW KPSEEMHHLM MDGYHTTGAF YMDGHFINDG GLYRLG*
Functional Description ? help Back to Top
Source Description
UniProtBinds to RNA (PubMed:17965274). Possible transcription factor that regulates genes involved in development. Mutations in KN-1 alter leaf development. Foci of cells along the lateral vein do not differentiate properly but continue to divide, forming knots. May participate in the switch from indeterminate to determinate cell fates. Probably binds to the DNA sequence 5'-TGAC-3'. {ECO:0000269|PubMed:17965274}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00675ChIP-seqTransfer from GRMZM2G017087Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapSeita.9G109500.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankDQ3174200.0DQ317420.1 Setaria italica KNOTTED1 homeodomain protein (KN1) mRNA, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004981913.10.0homeotic protein knotted-1
SwissprotP243450.0KN1_MAIZE; Homeotic protein knotted-1
TrEMBLA0A368SF910.0A0A368SF91_SETIT; Uncharacterized protein
STRINGGRMZM2G017087_P020.0(Zea mays)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP98863145
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G08150.11e-91KNOTTED-like from Arabidopsis thaliana
Publications ? help Back to Top
  1. Lowe B,Mathern J,Hake S
    Active Mutator elements suppress the knotted phenotype and increase recombination at the Kn1-O tandem duplication.
    Genetics, 1992. 132(3): p. 813-22
    [PMID:1334895]
  2. Sinha N,Hake S
    Mutant characters of knotted maize leaves are determined in the innermost tissue layers.
    Dev. Biol., 1990. 141(1): p. 203-10
    [PMID:2391001]
  3. Chen H,Jackson D,Kim JY
    Identification of evolutionarily conserved amino acid residues in homeodomain of KNOX proteins for intercellular trafficking.
    Plant Signal Behav, 2014. 9(3): p. e28355
    [PMID:24603432]
  4. Sinha NR,Williams RE,Hake S
    Overexpression of the maize homeo box gene, KNOTTED-1, causes a switch from determinate to indeterminate cell fates.
    Genes Dev., 1993. 7(5): p. 787-95
    [PMID:7684007]
  5. Greene B,Walko R,Hake S
    Mutator insertions in an intron of the maize knotted1 gene result in dominant suppressible mutations.
    Genetics, 1994. 138(4): p. 1275-85
    [PMID:7896105]
  6. Mathern J,Hake S
    Mu element-generated gene conversions in maize attenuate the dominant knotted phenotype.
    Genetics, 1997. 147(1): p. 305-14
    [PMID:9286690]