PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 676786322
Organism
Sisymbrium irio
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Sisymbrieae; Sisymbrium
Family E2F/DP
Protein Properties Length: 424aa    MW: 46665.8 Da    PI: 4.5435
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
676786322genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP83.61.6e-26125190171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                r+++sL+llt+kf++l++++e+g+++ln++a +L   +v  ++RRiYDi+NVLe+++liek+ kn+i+wkg
  676786322 125 RYDSSLGLLTKKFINLIKQAEDGNLDLNKAACTL---EV--QKRRIYDITNVLEGIGLIEKTLKNKIQWKG 190
                6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.2E-28122192IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.1E-32125190IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467859.07E-17127191IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023195.1E-24127190IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.00E-35217299No hitNo description
PfamPF164211.4E-24218297IPR032198E2F transcription factor, CC-MB domain
SuperFamilySSF1440742.62E-23219299No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 424 aa     Download sequence    Send to blast
MSDSQQEPDE NQPSKRQHHP SASSMKPPLV APGDYHRFDA AETPGGGVPD QLPEEIVIKS  60
SLKRKTDMDE LSELNAGVLQ TPVSGKGGKA KKSSRSYKSN KTGTLASGAN AGSPGNNFAQ  120
AGTCRYDSSL GLLTKKFINL IKQAEDGNLD LNKAACTLEV QKRRIYDITN VLEGIGLIEK  180
TLKNKIQWKG LDVSKPGETI ENIANLQYLI ENRPGGRESQ ERLTSLSEDD NNKRFLFVTE  240
DDIKNLPCFQ NKTLIAVKAP HGTTLEVPDP DEAGGYPQRR YRIILRSTMG PIDVYLVSQF  300
EERFEDIPNP DEPSNVPSTS GLLDKQDVAI PMEEDSTDKN MATQEVDDTQ RVYSDIESHD  360
FVDGIMKIVP PDLDMDVDYW LRSEMVSFDQ GAGPSYTTLE QPQTPSSPTP EGPEQSTGTR  420
STSS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A6e-23125191774PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMap676786322
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF4000001e-177AF400000.1 Thlaspi caerulescens E2F-related transcription factor 1 (E2F1) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006400728.20.0transcription factor E2FB isoform X1
SwissprotQ9FV710.0E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A1J3DY820.0A0A1J3DY82_NOCCA; Transcription factor E2FB (Fragment)
TrEMBLA0A1J3K7H50.0A0A1J3K7H5_NOCCA; Transcription factor E2FB
STRINGBostr.26527s0055.1.p0.0(Boechera stricta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.30.0E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]