PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 676755560
Organism
Sisymbrium irio
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Sisymbrieae; Sisymbrium
Family bHLH
Protein Properties Length: 454aa    MW: 50040.9 Da    PI: 5.664
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
676755560genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH361.2e-11274316754
                HHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHH CS
        HLH   7 erErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksL 54 
                ++ErrRR+++N+++  Lr+++Pk +      K++ a+iL  A++Y+k+L
  676755560 274 MAERRRRKKLNDRLYMLRSVVPKiS------KMDRASILGDAIDYLKEL 316
                79*********************66......****************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088815.866267316IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474596.8E-17270340IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003534.2E-14273322IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.9E-9273316IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.0E-15274330IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000834.63E-13274320No hitNo description
CDDcd048733.65E-7383443No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010444Biological Processguard mother cell differentiation
GO:0050826Biological Processresponse to freezing
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 454 aa     Download sequence    Send to blast
MNGDGVWLDN TGESSQPGDD NDESNSNSWV RNPDENWFNN NNTQPPNSLH NNQNDFRFSG  60
GFPLNPSENL LLLLQQSIDS SSPLQHFTLD SVPQQQQQQQ SFLATKACIA SLLNVPTSNN  120
MNNPFDEFGF DSGFLGQIHG NQTMNFAGMS SPPDFLSSRS LPETSVGAGN IFSPLEFGGL  180
ASGVFENRAK VLKPLEVLAS SGSQPTLFQK RAAMRQSSSS KLCNSESSSE LRRSSYEREV  240
DDNSTGIIDI SGLNDESDEH HKGKKKGMPA KNLMAERRRR KKLNDRLYML RSVVPKISKM  300
DRASILGDAI DYLKELLQRI NDLHTELEST PPTSSGLHPL TPTPQTLSYR VKEELCPSSS  360
LPSPKGQQAR IEVKLREGKA VNIHMFCGRR PGLLLSTMRA LDNLGLDVQQ AVISCFNGFA  420
LDVFRAEQCQ EGHDVLPEQI KAVLLDTAGY AGLL
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1263281KKKGMPAKNLMAERRRRKK
2275282ERRRRKKL
Functional Description ? help Back to Top
Source Description
UniProtMediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA (PubMed:18641265). Functions as a dimer with SPCH during stomatal initiation (PubMed:18641265, PubMed:28507175). {ECO:0000269|PubMed:18641265, ECO:0000269|PubMed:28507175}.
Cis-element ? help Back to Top
SourceLink
PlantRegMap676755560
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK1180110.0AK118011.1 Arabidopsis thaliana At1g12860 mRNA for putative bHLH transcription factor (bHLH033), complete cds, clone: RAFL19-21-N13.
GenBankBT0053770.0BT005377.1 Arabidopsis thaliana At1g12860 mRNA, complete cds.
GenBankEU3696700.0EU369670.1 Arabidopsis thaliana bHLH protein (SCREAM2) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006417184.10.0transcription factor SCREAM2
SwissprotQ9LPW30.0SCRM2_ARATH; Transcription factor SCREAM2
TrEMBLV4KZT90.0V4KZT9_EUTSA; Uncharacterized protein
STRINGXP_006417184.10.0(Eutrema salsugineum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM19522782
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G12860.10.0bHLH family protein
Publications ? help Back to Top
  1. Tarasov VA,Khadeeva NV,Mel'nik VA,Ezhova TA,Shestakov SV
    The Atlg12860 gene of Arabidopsis thaliana determines cathelicidin-like antimicrobial activity.
    Dokl. Biol. Sci., 2009.
    [PMID:19760875]
  2. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  3. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  4. Emmerstorfer A, et al.
    Over-expression of ICE2 stabilizes cytochrome P450 reductase in Saccharomyces cerevisiae and Pichia pastoris.
    Biotechnol J, 2015. 10(4): p. 623-35
    [PMID:25641738]
  5. Lee HG,Seo PJ
    The MYB96-HHP module integrates cold and abscisic acid signaling to activate the CBF-COR pathway in Arabidopsis.
    Plant J., 2015. 82(6): p. 962-77
    [PMID:25912720]
  6. Raissig MT,Abrash E,Bettadapur A,Vogel JP,Bergmann DC
    Grasses use an alternatively wired bHLH transcription factor network to establish stomatal identity.
    Proc. Natl. Acad. Sci. U.S.A., 2016. 113(29): p. 8326-31
    [PMID:27382177]
  7. Fu ZW,Wang YL,Lu YT,Yuan TT
    Nitric oxide is involved in stomatal development by modulating the expression of stomatal regulator genes in Arabidopsis.
    Plant Sci., 2016. 252: p. 282-289
    [PMID:27717464]
  8. de Marcos A, et al.
    A Mutation in the bHLH Domain of the SPCH Transcription Factor Uncovers a BR-Dependent Mechanism for Stomatal Development.
    Plant Physiol., 2017. 174(2): p. 823-842
    [PMID:28507175]