PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 676737504
Organism
Sisymbrium irio
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Sisymbrieae; Sisymbrium
Family E2F/DP
Protein Properties Length: 324aa    MW: 36957.3 Da    PI: 6.1876
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
676737504genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.73.5e-27146211171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                r+++sL+llt+kf++l++++e+g ++ln++a+ L   +v  ++RRiYDi+NVLe+++liek+ kn+irwkg
  676737504 146 RYDSSLGLLTKKFVNLIREAEDGSLDLNHCADVL---EV--QKRRIYDITNVLEGIGLIEKTTKNHIRWKG 211
                6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.1E-28142213IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.09E-17146209IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.2E-34146211IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023199.2E-25148211IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440746.8E-22222305No hitNo description
CDDcd146603.70E-29222307No hitNo description
PfamPF164218.3E-18227310IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000902Biological Processcell morphogenesis
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0042023Biological ProcessDNA endoreduplication
GO:0051782Biological Processnegative regulation of cell division
GO:0005667Cellular Componenttranscription factor complex
GO:0005730Cellular Componentnucleolus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
GO:0046982Molecular Functionprotein heterodimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 324 aa     Download sequence    Send to blast
MAATSKSGED PTLSYKNRSP FRFELLQSDP LYSSSTNRPF SVSQPLPPPP PPPPHWNDSI  60
TQKFQKSSRK NHRIQVGSIS SSNMPGETID IAKVIVKQES SSSPHHQYTK RELNKSKLNT  120
TTKHSKAAKR EAQQFGGPNG TSNNCRYDSS LGLLTKKFVN LIREAEDGSL DLNHCADVLE  180
VQKRRIYDIT NVLEGIGLIE KTTKNHIRWK GADNLGQLDL GDQISRLKLE VESMQFEESR  240
LDDLIRERQD ALRSLEEDEY CRRYMFMTEE DITSLPRFQN QTLLAIKAPT ASYIEVPDPD  300
ELKTDYWFES DAEVSLTDLW NNFC
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-24138212174PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00190DAPTransfer from AT1G47870Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMap676737504
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankJN9429730.0JN942973.1 Brassica juncea E2F transcription factor (E2Fc) mRNA, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006393509.11e-160transcription factor E2FC isoform X1
SwissprotQ9FV701e-158E2FC_ARATH; Transcription factor E2FC
TrEMBLR0I6M61e-160R0I6M6_9BRAS; Uncharacterized protein
STRINGXP_006305066.11e-161(Capsella rubella)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.11e-157E2F/DP family protein
Publications ? help Back to Top
  1. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  2. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  3. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]