PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

XP_011091424.1

Organism

Sesamum indicum

Taxonomic ID

4182

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Pedaliaceae; Sesamum

Family

bHLH

Protein Properties

Length: 404aa MW: 45226.8 Da PI: 5.4653

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_011091424.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	40.2	6.2e-13	197	248	1	55
CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +r++h ++Er+RR+++N+ + Lr+l+P++ + ++ + a+i A+e++++L+ XP_011091424.1 197 QRMTHIAVERNRRKQMNEHLRVLRSLMPSS---YVQRGDQASIIGGAIEFVRELE 248 79**************************...9***************9995 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:4.10.280.10	6.9E-14	195	251	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	1.62E-12	195	252	No hit	No description
PROSITE profile	PS50888	15.288	196	247	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	2.09E-16	196	261	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	3.2E-10	197	248	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	3.0E-9	202	253	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd04873	0.00294	330	394	No hit	No description
PROSITE profile	PS51671	8.551	330	404	IPR002912	ACT domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0010377	Biological Process	guard cell fate commitment
GO:0045597	Biological Process	positive regulation of cell differentiation
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051782	Biological Process	negative regulation of cell division
GO:0005634	Cellular Component	nucleus
GO:0016597	Molecular Function	amino acid binding
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 404 aa Download sequence Send to blast
MEKGGNFSGN FHGLDYISSL EVHNHQQQDL MKIGSTSADH NSNQMVDYML NNPPHTQPPP 60 PLPSNFCSSN SFDKLSFADV MQFADFGPKL ALNQSKNSEE ENGIDPVYFL KFPVLNEHKL 120 QEDHDNPVSS LMASQPLEEN NQEREDKGVG GGGGDGENTS VQLRFLGENL DKSPLAEAKS 180 KRKRPRTLKT SEEVESQRMT HIAVERNRRK QMNEHLRVLR SLMPSSYVQR GDQASIIGGA 240 IEFVRELEQL LQCLESQKRR RLYGDGQRPV GDPSMAIQQQ PQAPLVFPPM PIPNDQVKFV 300 EYESGLQEET AESKSCLADV EVKLLGFDAL IKILSRRRPG QLIKTIAALE DLQLNILHTN 360 ITTIEQTVLY SFNVKIGGEA RFTAEDIANS VQQIFSFIHA NGSI

Sequence ? help Back to Top

Protein Sequence Length: 404 aa Download sequence Send to blast

MEKGGNFSGN FHGLDYISSL EVHNHQQQDL MKIGSTSADH NSNQMVDYML NNPPHTQPPP  60
PLPSNFCSSN SFDKLSFADV MQFADFGPKL ALNQSKNSEE ENGIDPVYFL KFPVLNEHKL  120
QEDHDNPVSS LMASQPLEEN NQEREDKGVG GGGGDGENTS VQLRFLGENL DKSPLAEAKS  180
KRKRPRTLKT SEEVESQRMT HIAVERNRRK QMNEHLRVLR SLMPSSYVQR GDQASIIGGA  240
IEFVRELEQL LQCLESQKRR RLYGDGQRPV GDPSMAIQQQ PQAPLVFPPM PIPNDQVKFV  300
EYESGLQEET AESKSCLADV EVKLLGFDAL IKILSRRRPG QLIKTIAALE DLQLNILHTN  360
ITTIEQTVLY SFNVKIGGEA RFTAEDIANS VQQIFSFIHA NGSI

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	197	208	RMTHIAVERNRR
2	257	261	KRRRL

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269\|PubMed:17088607, ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267, ECO:0000269\|PubMed:24571519, ECO:0000269\|PubMed:24654956}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_011091424.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269\|PubMed:22442411}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AM425576	3e-31	AM425576.2 Vitis vinifera contig VV78X098456.7, whole genome shotgun sequence.
GenBank	KM111498	3e-31	KM111498.1 Vitis vinifera clone 3 FAMA (FAMA) gene, complete cds.
GenBank	KM111499	3e-31	KM111499.1 Vitis riparia clone 1 FAMA (E) (FAMA) gene, complete cds.
GenBank	KM111500	3e-31	KM111500.1 Vitis riparia clone 4 FAMA(E) (FAMA) mRNA, complete cds.
GenBank	KM111501	3e-31	KM111501.1 Vitis riparia clone 5 FAMAi1(E) (FAMA) mRNA, complete cds.
GenBank	KM111502	3e-31	KM111502.1 Vitis riparia clone 4 FAMA(L) (FAMA) mRNA, complete cds.
GenBank	KM111503	3e-31	KM111503.1 Vitis vinifera clone 1 FAMA(L) (FAMA) mRNA, complete cds.
GenBank	KM111504	3e-31	KM111504.1 Vitis riparia clone 2 FAMAi2(L) (FAMA) mRNA, complete cds.
GenBank	KM111505	3e-31	KM111505.1 Vitis vinifera clone 1 FAMAi2(L) (FAMA) mRNA, complete cds.
GenBank	KM224875	3e-31	KM224875.1 Vitis riparia clone 3 FAMA(E) (FAMA) gene, complete cds.
GenBank	KM224876	3e-31	KM224876.1 Vitis riparia clone 3 FAMA(E) (FAMA) mRNA, complete cds.
GenBank	KM224877	3e-31	KM224877.1 Vitis riparia clone 5 FAMA(L) (FAMA) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011091423.1	0.0	transcription factor FAMA isoform X3
Swissprot	Q56YJ8	1e-143	FAMA_ARATH; Transcription factor FAMA
TrEMBL	A0A068TT28	0.0	A0A068TT28_COFCA; Uncharacterized protein
STRING	cassava4.1_024031m	0.0	(Manihot esculenta)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G24140.1	1e-132	bHLH family protein

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Matos JL, et al. Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] Chen L, et al. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] Li X,Yang R,Chen H The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]