PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Sphfalx0063s0055.1.p
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Bryophyta; Sphagnophytina; Sphagnopsida; Sphagnales; Sphagnaceae; Sphagnum
Family E2F/DP
Protein Properties Length: 386aa    MW: 42242.5 Da    PI: 5.0001
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Sphfalx0063s0055.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.51.9e-2761126171
               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                           r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Sphfalx0063s0055.1.p  61 RYDSSLGLLTKKFVNLINQAEDGVLDLNKAADTL---HV--QKRRIYDITNVLEGVGLIEKKLKNRIQWKG 126
                           6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.4E-2957127IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-3461126IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.22E-1761124IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.5E-2463126IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440744.97E-32140242No hitNo description
CDDcd146602.83E-49140242No hitNo description
PfamPF164212.4E-34142241IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 386 aa     Download sequence    Send to blast
MATNGWSGFS SADASPGPMH TGRRGSRSKS AKQLKNGPHT PGSSGIGSPT ASAPTPSGTC  60
RYDSSLGLLT KKFVNLINQA EDGVLDLNKA ADTLHVQKRR IYDITNVLEG VGLIEKKLKN  120
RIQWKGLGAG RPELAKGDES VLQAEVKKLH MEEQSLDERI REMREQLRTL SENEKNKQWL  180
YVTDEDIKSL SCFQNETLIA IKAPHGTTLE VPDPDEAVEY PHRRFQILLR STMGPIDVYL  240
VSRFEGKFEE MNATDPPVDT PPSAIATSQQ HESTPLMEEL GRSMSELGPL GKPDASIPSS  300
ELTNPHNDPA SGIMKIMPAE VTMDTDYWFL SDVSVGITDI WKNDTSNAMW DEMVRLNAEF  360
GIGEIGSPHP HTPPSGSTLE VEPVS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A5e-2756128175PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024368555.11e-180transcription factor E2FA-like isoform X2
RefseqXP_024368556.11e-180transcription factor E2FA-like isoform X2
SwissprotQ9FNY01e-117E2FA_ARATH; Transcription factor E2FA
TrEMBLA9RQX01e-178A9RQX0_PHYPA; E2F transcription factor3
STRINGPP1S22_60V6.11e-179(Physcomitrella patens)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-120E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]