PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Sphfalx0031s0081.1.p
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Bryophyta; Sphagnophytina; Sphagnopsida; Sphagnales; Sphagnaceae; Sphagnum
Family LSD
Protein Properties Length: 188aa    MW: 19802.2 Da    PI: 7.9525
Description LSD family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Sphfalx0031s0081.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
               zf-LSD1  1 CggCrtlLsYPrGApsVRCalCdtV 25
                          CggCrtlL YP GA++VRCalC tV
  Sphfalx0031s0081.1.p 16 CGGCRTLLVYPQGASNVRCALCSTV 40
                          ***********************99 PP

               zf-LSD1  1 CggCrtlLsYPrGApsVRCalCdtV 25
                          CggCrtlL+Y rGA+sV+C++C+tV
  Sphfalx0031s0081.1.p 55 CGGCRTLLMYMRGATSVQCSCCHTV 79
                          ************************9 PP

               zf-LSD1   1 CggCrtlLsYPrGApsVRCalCdtV 25 
                           CggC+ +L+Y +GA sV+CalC+ V
  Sphfalx0031s0081.1.p  93 CGGCGMTLMYAYGAQSVKCALCQYV 117
                           ***********************87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
TIGRFAMsTIGR010531.1E-151343IPR005735Zinc finger, LSD1-type
PfamPF069439.1E-131640IPR005735Zinc finger, LSD1-type
TIGRFAMsTIGR010536.8E-165281IPR005735Zinc finger, LSD1-type
PfamPF069431.3E-125579IPR005735Zinc finger, LSD1-type
TIGRFAMsTIGR010531.0E-1090120IPR005735Zinc finger, LSD1-type
PfamPF069431.2E-1193117IPR005735Zinc finger, LSD1-type
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009814Biological Processdefense response, incompatible interaction
GO:0034052Biological Processpositive regulation of plant-type hypersensitive response
GO:2000121Biological Processregulation of removal of superoxide radicals
Sequence ? help Back to Top
Protein Sequence    Length: 188 aa     Download sequence    Send to blast
Functional Description ? help Back to Top
Source Description
UniProtNegative regulator of reactive oxygen-induced cell death, cold stress-induced cell death, pathogen-induced hypersensitive response (HR), basal disease resistance. May be involved in the induction of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death. Antagonizes the function of BZIP10, a positive regulator of cell death, by interacting in the cytoplasm and preventing its nuclear localization. Controls lysigenous aerenchyma in hypocotyls under root hypoxia. Required for leaf acclimation in response to excess excitation energy. {ECO:0000269|PubMed:10550898, ECO:0000269|PubMed:11595797, ECO:0000269|PubMed:11844114, ECO:0000269|PubMed:12732715, ECO:0000269|PubMed:15347794, ECO:0000269|PubMed:16957775, ECO:0000269|PubMed:18055613, ECO:0000269|PubMed:18790826, ECO:0000269|PubMed:20456049, ECO:0000269|PubMed:21097903}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By methyl viologen. {ECO:0000269|PubMed:20456049}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024389231.12e-86protein LOL1-like
SwissprotP940778e-53LSD1_ARATH; Protein LSD1
TrEMBLA0A2K1KBH62e-90A0A2K1KBH6_PHYPA; Uncharacterized protein
STRINGPP1S11_54V6.17e-86(Physcomitrella patens)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32540.11e-53lsd one like 1
Publications ? help Back to Top
  1. Spedaletti V, et al.
    Characterization of a lysine-specific histone demethylase from Arabidopsis thaliana.
    Biochemistry, 2008. 47(17): p. 4936-47
  2. Szechyńska-Hebda M,Czarnocka W,Hebda M,Bernacki MJ,Karpiński S
    PAD4, LSD1 and EDS1 regulate drought tolerance, plant biomass production, and cell wall properties.
    Plant Cell Rep., 2016. 35(3): p. 527-39
  3. Czarnocka W, et al.
    The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator.
    Plant Cell Environ., 2017. 40(11): p. 2644-2662
  4. Bernacki MJ, et al.
    LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana.
    Physiol Plant, 2019. 165(2): p. 369-382