PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Sobic.001G106200.1.p
Common NameSb01g009480, SORBIDRAFT_01g009480
Organism
Sorghum bicolor
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum
Family TALE
Protein Properties Length: 361aa    MW: 39863.9 Da    PI: 7.0714
Description TALE family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Sobic.001G106200.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox26.98.2e-092893242055
                           HHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHH CS
              Homeobox  20 eknrypsaeereeLAkklgLterqVkvWFqNrRake 55 
                           +k +yps++++  LA+++gL+ +q+ +WF N+R ++
  Sobic.001G106200.1.p 289 YKWPYPSETQKVALAESTGLDLKQINNWFINQRKRH 324
                           5679*****************************885 PP
2ELK37.16.7e-13244265122
                   ELK   1 ELKhqLlrKYsgyLgsLkqEFs 22 
                           ELKh+Ll+KYsgyL+sLkqE+s
  Sobic.001G106200.1.p 244 ELKHHLLKKYSGYLSSLKQELS 265
                           9*******************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM012557.2E-20104148IPR005540KNOX1
PfamPF037901.9E-21105147IPR005540KNOX1
SMARTSM012568.3E-28155206IPR005541KNOX2
PfamPF037918.9E-23161204IPR005541KNOX2
SMARTSM01188660164184IPR005539ELK domain
PfamPF037898.2E-10244265IPR005539ELK domain
PROSITE profilePS5121311.331244264IPR005539ELK domain
SMARTSM011884.9E-7244265IPR005539ELK domain
PROSITE profilePS5007112.487264327IPR001356Homeobox domain
SuperFamilySSF466892.78E-19265340IPR009057Homeodomain-like
SMARTSM003894.2E-12266331IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.607.5E-28269329IPR009057Homeodomain-like
CDDcd000868.79E-12276328No hitNo description
PfamPF059206.8E-16284323IPR008422Homeobox KN domain
PROSITE patternPS000270302325IPR017970Homeobox, conserved site
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 361 aa     Download sequence    Send to blast
MEEITHHFGV GASSHSHGHG HGQHHHHHHP WASSLSAVVA PPPQQPPTAG LPLTLNTVAA  60
TGNSGASGNP VLQLANGGSL LDACVNVKAK GEPSSSSPYA GDLEAIKAKI ISHPHYYSLL  120
AAYLECKKVG APPDVSARLT AMAQELEARQ RTALSGLGAA TEPELDQFME AYHEMLVKFK  180
EELTRPLQEA MEFMRRVESQ LNSLSISGRS LRNILSSGSS EEDQEGSGGE TELPEVDVHG  240
VDQELKHHLL KKYSGYLSSL KQELSKKKKK GKLPKEARQQ LLSWWDLHYK WPYPSETQKV  300
ALAESTGLDL KQINNWFINQ RKRHWKPSEE MHHLMMDGYH TNTFFMDGHF INDGGLYRLG  360
*
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed throughout apical and vegetative meristem during development. Down-regulated as leaves and floral organs are initiated. {ECO:0000269|PubMed:1362381}.
UniprotTISSUE SPECIFICITY: Expressed in apical meristems of vegetative and floral stems as well as in the underlying ground meristem. Specifically expressed in vascular bundles developing both in the leaf and stem. Very low levels of expression in leaves.
Functional Description ? help Back to Top
Source Description
UniProtBinds to RNA (PubMed:17965274). Possible transcription factor that regulates genes involved in development. Mutations in KN-1 alter leaf development. Foci of cells along the lateral vein do not differentiate properly but continue to divide, forming knots. May participate in the switch from indeterminate to determinate cell fates. Probably binds to the DNA sequence 5'-TGAC-3'. {ECO:0000269|PubMed:17965274}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00675ChIP-seqTransfer from GRMZM2G017087Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapSobic.001G106200.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankDQ3174170.0DQ317417.1 Sorghum bicolor KNOTTED1 homeodomain protein (KN1) mRNA, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_002463952.10.0homeotic protein knotted-1
SwissprotP243450.0KN1_MAIZE; Homeotic protein knotted-1
TrEMBLC5WM190.0C5WM19_SORBI; Uncharacterized protein
STRINGSb01g009480.10.0(Sorghum bicolor)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP98863145
Representative plantOGRP16717148
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G08150.15e-92KNOTTED-like from Arabidopsis thaliana
Publications ? help Back to Top
  1. Lowe B,Mathern J,Hake S
    Active Mutator elements suppress the knotted phenotype and increase recombination at the Kn1-O tandem duplication.
    Genetics, 1992. 132(3): p. 813-22
    [PMID:1334895]
  2. Sinha N,Hake S
    Mutant characters of knotted maize leaves are determined in the innermost tissue layers.
    Dev. Biol., 1990. 141(1): p. 203-10
    [PMID:2391001]
  3. Chen H,Jackson D,Kim JY
    Identification of evolutionarily conserved amino acid residues in homeodomain of KNOX proteins for intercellular trafficking.
    Plant Signal Behav, 2014. 9(3): p. e28355
    [PMID:24603432]
  4. Sinha NR,Williams RE,Hake S
    Overexpression of the maize homeo box gene, KNOTTED-1, causes a switch from determinate to indeterminate cell fates.
    Genes Dev., 1993. 7(5): p. 787-95
    [PMID:7684007]
  5. Greene B,Walko R,Hake S
    Mutator insertions in an intron of the maize knotted1 gene result in dominant suppressible mutations.
    Genetics, 1994. 138(4): p. 1275-85
    [PMID:7896105]
  6. Mathern J,Hake S
    Mu element-generated gene conversions in maize attenuate the dominant knotted phenotype.
    Genetics, 1997. 147(1): p. 305-14
    [PMID:9286690]