PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Psi001111
Organism
Picea sitchensis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Acrogymnospermae; Pinidae; Pinales; Pinaceae; Picea
Family C2H2
Protein Properties Length: 532aa    MW: 61414.4 Da    PI: 8.479
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
gnl|UG|Psi#S41649308PU_unrefUnigeneView CDS
PUT-183a-Picea_sitchensis-14946PU_refplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H211.60.00085291313123
                EEETTTTEEESSHHHHHHHHHHT CS
    zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                y C+ C    +rk++L+rH+r++
  Psi001111 291 YFCEFCLNFMKRKEQLQRHMRKC 313
                78*******************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541605.59E-22145258IPR016197Chromo domain-like
Gene3DG3DSA:2.30.30.2703.4E-37147218No hitNo description
PfamPF117171.0E-20148205IPR025995RNA binding activity-knot of a chromodomain
CDDcd000242.55E-7161207No hitNo description
SMARTSM002986.0E-7162221IPR000953Chromo/chromo shadow domain
Gene3DG3DSA:2.30.30.2703.4E-37252302No hitNo description
PROSITE profilePS5172674.612257528IPR002717Histone acetyltransferase domain, MYST-type
SuperFamilySSF557291.85E-110258529IPR016181Acyl-CoA N-acyltransferase
Gene3DG3DSA:3.40.630.301.0E-72316459IPR016181Acyl-CoA N-acyltransferase
PfamPF018535.4E-84318495IPR002717Histone acetyltransferase domain, MYST-type
CDDcd043010.00221369427No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0016573Biological Processhistone acetylation
GO:0005634Cellular Componentnucleus
GO:0004402Molecular Functionhistone acetyltransferase activity
Sequence ? help Back to Top
Protein Sequence    Length: 532 aa     Download sequence    Send to blast
GFGLLKANIS GKTKPDWYTD DQVQGVIYTT SIYEHLQRAS GRLTIAAAAS LISMLKQQQQ  60
QQKKKTGLEN SVDKMGMGSA DESGRFSTSN GQFMNMNNGV IKEEWKGGVP VVPPAPTTVP  120
VITNVKVETP SSPDHDLVRK RKLGFLPLEV GTRVLCKWRD GKFHPVKIIE RRKLPNGTTN  180
DYEYYVHYTE FNRRLDEWVK LEQLELDSVE TDADEKVDDK AGSLKMTRHQ KRKIDETHVE  240
GNEELDAASL REHEEFTKVK NIKKIELERY EIETWYFSPF PAEYNSCEKL YFCEFCLNFM  300
KRKEQLQRHM RKCDLKHPPG EKIYRSGTLS MFEVDGKKNK VYAQNLCYLA KLFLDHKTLY  360
YDVDLFLFYI LCECDDRGCH MVGYFSKEKH SEESYNLACI LTLPPYQRKG YGKFLISFSY  420
ELSKKEGKVG TPERPLSDLG LLSYRGYWTR VLLDILKKHK NNISIKELSD MTAIKAEDVL  480
STLQGLDLIQ YRKGQHAICA DPKVLDRHLK AVGRGGLEVD VCKLIWTPYK EQ
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4dnc_A1e-1142535321282Histone acetyltransferase KAT8
4dnc_B1e-1142535321282Histone acetyltransferase KAT8
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Psi.70750.0shoot
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in cotyledons, leaves, stems, roots and, at higher levels in developing flowers, particularly in the anthers and gynoecia (PubMed:19040736). Constitutively expressed in all tissues, predominantly in shoot apical meristem (PubMed:23273925). {ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:23273925}.
Functional Description ? help Back to Top
Source Description
UniProtHistone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269|PubMed:17877703, ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:22170978, ECO:0000269|PubMed:23273925}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269|PubMed:22170978}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010261128.10.0PREDICTED: histone acetyltransferase of the MYST family 1-like isoform X1
SwissprotQ9FLF70.0MYST1_ARATH; Histone acetyltransferase of the MYST family 1
TrEMBLA9NUX90.0A9NUX9_PICSI; Histone acetyltransferase
STRINGXP_010261128.10.0(Nelumbo nucifera)
Publications ? help Back to Top
  1. Latrasse D, et al.
    The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis.
    BMC Plant Biol., 2008. 8: p. 121
    [PMID:19040736]
  2. Campi M,D'Andrea L,Emiliani J,Casati P
    Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA.
    Plant Physiol., 2012. 158(2): p. 981-95
    [PMID:22170978]
  3. Bari A,Orazova S,Ivashchenko A
    miR156- and miR171-binding sites in the protein-coding sequences of several plant genes.
    Biomed Res Int, 2013. 2013: p. 307145
    [PMID:23936788]
  4. Xu Y, et al.
    Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
    Nucleic Acids Res., 2014. 42(17): p. 10960-74
    [PMID:25183522]
  5. Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB
    3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana.
    J Mol Model, 2016. 22(11): p. 256
    [PMID:27709438]
  6. Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P
    HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1179
    [PMID:28740501]