PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_008239700.1
Organism
Prunus mume
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Amygdaleae; Prunus
Family E2F/DP
Protein Properties Length: 359aa    MW: 40148.1 Da    PI: 9.3807
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_008239700.1genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP71.78.5e-232085171
         E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    rk+ksL+ll+++fl l+++   + + l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  XP_008239700.1 20 RKQKSLGLLCSNFLGLYNRDGVTSIGLDDAASRL---GV--ERRRIYDIVNVLESVGVLARKAKNQYSWKG 85
                    79*****************999************...**..****************************98 PP
2E2F_TDP771.9e-24151232171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvkn.krRRiYDilNVLealnliek.....kekneirwkg 71 
                     r+eksL lltq+f+kl+ +s+e++++l++vak L+ +      +++ k+RRiYDi+NVL+++nliek     ++k++++w g
  XP_008239700.1 151 RREKSLALLTQNFVKLFVCSTEEMISLDDVAKLLLGDaqsasAMRTaKVRRIYDIANVLSSMNLIEKthtpdTRKPAFKWLG 232
                     689***************************************4444288**********************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.1E-251686IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467857.42E-161983IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.8E-272085IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-192185IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.104.6E-24147233IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.4E-30151232IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.67E-12153233IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.3E-19153232IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 359 aa     Download sequence    Send to blast
MAAPAAPPSG PSTRKHGYSR KQKSLGLLCS NFLGLYNRDG VTSIGLDDAA SRLGVERRRI  60
YDIVNVLESV GVLARKAKNQ YSWKGFGAIP NALQELREEG LRENCINFAG NDDAKVSDDE  120
DDEERCGSQP NDKSNPTVNP QPPADQKPDN RREKSLALLT QNFVKLFVCS TEEMISLDDV  180
AKLLLGDAQS ASAMRTAKVR RIYDIANVLS SMNLIEKTHT PDTRKPAFKW LGLRGKEENL  240
VPNESRKRAF GTDITNVISK RGKLESSVGG ELDAQKQRQH DLEDSKDGSK SYQFGPFAPV  300
TIARPGNSNM RRVHDWEKLT STYRPQYQNQ ALKDLFSHYM EAWKSWYSEV AGKNPIRIS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-36192243228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_008239700.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008239700.10.0PREDICTED: E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ41e-135E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A251PA560.0A0A251PA56_PRUPE; Uncharacterized protein
STRINGXP_008239700.10.0(Prunus mume)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-137DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]