PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Pahal.C01762.2
Organism
Panicum hallii
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Panicodae; Paniceae; Panicinae; Panicum
Family bHLH
Protein Properties Length: 423aa    MW: 44612.4 Da    PI: 4.9885
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Pahal.C01762.2genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH41.32.8e-13186237155
                     CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
             HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                     +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A+e+I++L+
  Pahal.C01762.2 186 QRMTHIAVERNRRRQMNEYLRILRSLMPGS---YVQRGDQASIIGGAIEFIRELE 237
                     79****************************...9******************996 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000837.40E-14184241No hitNo description
Gene3DG3DSA:4.10.280.102.5E-13184240IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.11E-16185250IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.847185236IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.1E-10186237IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.0E-9191242IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS516718.994348422IPR002912ACT domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 423 aa     Download sequence    Send to blast
MDKEGSHHSH LDSFTPLDGA APGDQTGGGA EMVDYILGQA PPPAQPPPPQ SQVSFDKLSF  60
SDVLQFADFG PKLALNQPAA SAGAHEGVDD PGDDEDDDDG YFFRFQSLSS LPGGAGQHHA  120
DREGSKTTAD DGGAHDGGGG GGVSESTTLV QHADGGGRAE KGGDQGKSGR RKRPRTVKTS  180
EEVESQRMTH IAVERNRRRQ MNEYLRILRS LMPGSYVQRG DQASIIGGAI EFIRELEQLI  240
QCLESQKRRR LYGGSGDAPR PVVDAAGAGA PTSTQQHHQT QVPPAAAFFP PSLPFPVASS  300
GGGDGGAAKI LDLEAGGADA AAGLREEVAE NKSCLADIEV RALGADAMIK ILSRRRPGQL  360
IKTIAALEDM QMSILHTNIT TIEQTVLYSF NVKILGEARY SAEDIAGAVH QILSFIDVNY  420
AL*
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1186197RMTHIAVERNRR
2246250KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKJ7277501e-137KJ727750.1 Zea mays clone pUT5691 bHLH transcription factor (bHLH22) mRNA, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_025805325.10.0transcription factor FAMA isoform X2
SwissprotQ56YJ81e-113FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A2S3H9630.0A0A2S3H963_9POAL; Uncharacterized protein
TrEMBLA0A2T7E9Q60.0A0A2T7E9Q6_9POAL; Uncharacterized protein
STRINGPavir.J04021.1.p0.0(Panicum virgatum)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-53bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]