PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Pbr010366.1

Organism

Pyrus bretschneideri

Taxonomic ID

225117

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Pyrus

Family

E2F/DP

Protein Properties

Length: 430aa MW: 47527.1 Da PI: 4.6161

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Pbr010366.1	genome	CPETR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.1	2.6e-27	104	169	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+irwkg Pbr010366.1 104 RYDSSLGLLTKKFINLIKRAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 169 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	4.4E-29	101	171	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	5.89E-17	104	167	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	4.5E-34	104	169	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.3E-24	106	169	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.90E-49	182	286	No hit	No description
SuperFamily	SSF144074	6.28E-34	182	286	No hit	No description
Pfam	PF16421	5.1E-33	185	284	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 430 aa Download sequence Send to blast
MCCLIWSEGT DLEVDFQVVV FGSFLESIVA HGQLTRKDNN EVGYSDWTNS PGNTNVIQSP 60 LQTPVSAKGG RVNNRSKASK GGRSGPQTPV SIVGSPSTPA GSCRYDSSLG LLTKKFINLI 120 KRAEDGILDL NKAAETLEVQ KRRIYDITNV LEGIGLIEKK LKNRIRWKGF DASMPGELDG 180 DLSILQAEVE NLSSQERRLD DRIREMQEKL RDLSEDENNR KWLFVTEDDI KGLPCFHNET 240 LIAIKAPHGT TLEVPDPDEA VDYPQRRYRI ILRSTMGPID VYLVSQFEEK FEDVHGAEPP 300 VNFPIASGSG SNEHPTTEVV TVESSGKEIE PWLQQAHHAC SDMNASQEFA GGMMKIVPSD 360 VDNDADYWLL SDAEVSITDM WRTDSGVGWN GTDILHADFG VTDVSTSRPQ TPPSRVVEVP 420 SHAVNFAQR*

Sequence ? help Back to Top

Protein Sequence Length: 430 aa Download sequence Send to blast

MCCLIWSEGT DLEVDFQVVV FGSFLESIVA HGQLTRKDNN EVGYSDWTNS PGNTNVIQSP  60
LQTPVSAKGG RVNNRSKASK GGRSGPQTPV SIVGSPSTPA GSCRYDSSLG LLTKKFINLI  120
KRAEDGILDL NKAAETLEVQ KRRIYDITNV LEGIGLIEKK LKNRIRWKGF DASMPGELDG  180
DLSILQAEVE NLSSQERRLD DRIREMQEKL RDLSEDENNR KWLFVTEDDI KGLPCFHNET  240
LIAIKAPHGT TLEVPDPDEA VDYPQRRYRI ILRSTMGPID VYLVSQFEEK FEDVHGAEPP  300
VNFPIASGSG SNEHPTTEVV TVESSGKEIE PWLQQAHHAC SDMNASQEFA GGMMKIVPSD  360
VDNDADYWLL SDAEVSITDM WRTDSGVGWN GTDILHADFG VTDVSTSRPQ TPPSRVVEVP  420
SHAVNFAQR*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-24	96	169	2	73	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Pbr010366.1

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009349221.1	0.0	PREDICTED: transcription factor E2FA-like
Swissprot	Q9FNY0	1e-154	E2FA_ARATH; Transcription factor E2FA
TrEMBL	M5W8E6	0.0	M5W8E6_PRUPE; Uncharacterized protein
STRING	XP_009349217.1	0.0	(Pyrus x bretschneideri)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-159	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]