PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

MA_46112g0010

Organism

Picea abies

Taxonomic ID

3329

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Acrogymnospermae; Pinidae; Pinales; Pinaceae; Picea

Family

bHLH

Protein Properties

Length: 438aa MW: 48185.1 Da PI: 7.502

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MA_46112g0010	genome	ConGenIE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	36.2	1.1e-11	237	279	7	54
HHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHH CS HLH 7 erErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksL 54 ++ErrRR+++N+++ Lr+++Pk + K++ a+iL A+eY+k+L MA_46112g0010 237 MAERRRRKKLNDRLYMLRSVVPKiS------KMDRASILGDAIEYLKEL 279 79*******************66......**************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50888	15.58	230	279	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	1.15E-16	233	301	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	2.5E-9	236	279	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	6.2E-14	236	285	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	7.7E-16	237	293	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	2.34E-11	237	283	No hit	No description
SuperFamily	SSF55021	8.24E-5	365	436	No hit	No description
CDD	cd04873	2.75E-8	366	429	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0010444	Biological Process	guard mother cell differentiation
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0050826	Biological Process	response to freezing
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 438 aa Download sequence Send to blast
MRNVTAVYGC QKTAKQKGWM KEGGGEAIEM GGWVREKASR ARQDGQWRVG KGVLLKKRKL 60 LIILFQSALE REQMESFKAM LEDEWYMPGG QDSNSLMDEL AYSSSFVSAP ETSSVFSLDP 120 SRLQSFMSFV PKKKTLPNTT MSSLLVAESP NTRALRKSPK GDSIRVQSSN LEEEGEEPLG 180 GEDNMDDESG GGGSGLLYET DDAKPEQVMS GQDGPAPGPG PPADKGKKKG LPAKNLMAER 240 RRRKKLNDRL YMLRSVVPKI SKMDRASILG DAIEYLKELL QRINDLHTEL EGTSERPLSA 300 TALPLPLNLP VPSPFHYPLT PSTPPLIPCR IKEECPPISL PAHSEASDSQ PPRVEVKTRD 360 GRSLNIHMFC ARRPGLLLST MRALDELGLD VQQAVISCFN GFALDVFRAE QSRGGGDIAL 420 EEIKAVLLHT ANSHQITM

Sequence ? help Back to Top

Protein Sequence Length: 438 aa Download sequence Send to blast

MRNVTAVYGC QKTAKQKGWM KEGGGEAIEM GGWVREKASR ARQDGQWRVG KGVLLKKRKL  60
LIILFQSALE REQMESFKAM LEDEWYMPGG QDSNSLMDEL AYSSSFVSAP ETSSVFSLDP  120
SRLQSFMSFV PKKKTLPNTT MSSLLVAESP NTRALRKSPK GDSIRVQSSN LEEEGEEPLG  180
GEDNMDDESG GGGSGLLYET DDAKPEQVMS GQDGPAPGPG PPADKGKKKG LPAKNLMAER  240
RRRKKLNDRL YMLRSVVPKI SKMDRASILG DAIEYLKELL QRINDLHTEL EGTSERPLSA  300
TALPLPLNLP VPSPFHYPLT PSTPPLIPCR IKEECPPISL PAHSEASDSQ PPRVEVKTRD  360
GRSLNIHMFC ARRPGLLLST MRALDELGLD VQQAVISCFN GFALDVFRAE QSRGGGDIAL  420
EEIKAVLLHT ANSHQITM

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	226	244	KKKGLPAKNLMAERRRRKK
2	238	245	ERRRRKKL

Functional Description ? help Back to Top
Source	Description
UniProt	Mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA (PubMed:18641265). Functions as a dimer with SPCH during stomatal initiation (PubMed:18641265, PubMed:28507175). {ECO:0000269\|PubMed:18641265, ECO:0000269\|PubMed:28507175}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_021673395.1	8e-95	transcription factor ICE1-like isoform X1
Swissprot	Q9LPW3	3e-82	SCRM2_ARATH; Transcription factor SCREAM2
TrEMBL	A0A1W6E001	2e-93	A0A1W6E001_HEVBR; ICE-like protein 1
TrEMBL	A0A384SKP9	2e-93	A0A384SKP9_HEVBR; ICE-like protein 1
STRING	cassava4.1_005158m	1e-92	(Manihot esculenta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Representative plant	OGRP557	16	78

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G12860.1	6e-80	bHLH family protein

Publications ? help Back to Top
Tarasov VA,Khadeeva NV,Mel'nik VA,Ezhova TA,Shestakov SV The Atlg12860 gene of Arabidopsis thaliana determines cathelicidin-like antimicrobial activity. Dokl. Biol. Sci., 2009. [PMID:19760875] Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Emmerstorfer A, et al. Over-expression of ICE2 stabilizes cytochrome P450 reductase in Saccharomyces cerevisiae and Pichia pastoris. Biotechnol J, 2015. 10(4): p. 623-35 [PMID:25641738] Lee HG,Seo PJ The MYB96-HHP module integrates cold and abscisic acid signaling to activate the CBF-COR pathway in Arabidopsis. Plant J., 2015. 82(6): p. 962-77 [PMID:25912720] Raissig MT,Abrash E,Bettadapur A,Vogel JP,Bergmann DC Grasses use an alternatively wired bHLH transcription factor network to establish stomatal identity. Proc. Natl. Acad. Sci. U.S.A., 2016. 113(29): p. 8326-31 [PMID:27382177] Fu ZW,Wang YL,Lu YT,Yuan TT Nitric oxide is involved in stomatal development by modulating the expression of stomatal regulator genes in Arabidopsis. Plant Sci., 2016. 252: p. 282-289 [PMID:27717464] de Marcos A, et al. A Mutation in the bHLH Domain of the SPCH Transcription Factor Uncovers a BR-Dependent Mechanism for Stomatal Development. Plant Physiol., 2017. 174(2): p. 823-842 [PMID:28507175]