PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

MA_13142g0010

Organism

Picea abies

Taxonomic ID

3329

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Acrogymnospermae; Pinidae; Pinales; Pinaceae; Picea

Family

E2F/DP

Protein Properties

Length: 255aa MW: 28768.2 Da PI: 4.7362

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MA_13142g0010	genome	ConGenIE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	85.9	2.9e-27	82	146	1	70
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 r+++sL+llt+kf++l++++++g+++ln++a++L dv ++RRiYDi+NVLe+++liekk kn+irwk MA_13142g0010 82 RYDSSLGLLTKKFISLIKQADDGVLDLNKAADTL---DV--QKRRIYDITNVLEGIGLIEKKLKNRIRWK 146 6899****************************.....****************************7 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	7.1E-28	79	146	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	9.87E-18	82	145	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	3.8E-32	82	147	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	2.9E-24	84	146	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.10E-36	152	237	No hit	No description
SuperFamily	SSF144074	3.4E-27	153	244	No hit	No description
Pfam	PF16421	4.6E-24	157	234	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 255 aa Download sequence Send to blast
MSLGKRRAET EEDHEIESNE WPTSQGYAEA VNSPILTPVS GTSGRRYNRS KLAKSMRTGP 60 QTPASNIGSP SSNVHTPVST CRYDSSLGLL TKKFISLIKQ ADDGVLDLNK AADTLDVQKR 120 RIYDITNVLE GIGLIEKKLK NRIRWKPGEV DDEVTSLQAE VENLYVEERR VDEKIREMRE 180 RLRILSEDEN NQKWLYVTEE DIKSLPCFQN ETLIAIKAPH GTTLEVPDPD EVSFDFQNIC 240 SPLQSSIGVQ GYLDD

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	7e-26	77	146	2	72	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	BT122815	0.0	BT122815.1 Picea sitchensis clone WS0461_J06 unknown mRNA.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010246568.1	1e-121	PREDICTED: transcription factor E2FA
Swissprot	Q9FV71	2e-87	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A200Q9I6	1e-121	A0A200Q9I6_9MAGN; Transcription factor E2F/dimerization partner (TDP)
STRING	XP_010246568.1	1e-120	(Nelumbo nucifera)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Representative plant	OGRP1225	17	49

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	6e-90	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]