PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

MA_130776g0010

Organism

Picea abies

Taxonomic ID

3329

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Acrogymnospermae; Pinidae; Pinales; Pinaceae; Picea

Family

bHLH

Protein Properties

Length: 356aa MW: 39396.8 Da PI: 6.4487

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MA_130776g0010	genome	ConGenIE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	39.6	9.7e-13	161	212	1	55
CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +r +h e+Er+RR+++N ++ Lr+l+P++ + ++ + a+i A++ +k+L+ MA_130776g0010 161 QRITHIEVERNRRKQMNAHLDVLRSLIPQS---YIQRGDQASIIGGAIDLVKELE 212 799*************************...9***************9995 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF47459	6.02E-15	153	221	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	14.9	160	211	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	6.73E-12	160	216	No hit	No description
Pfam	PF00010	7.4E-10	161	212	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	2.9E-12	161	215	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	1.5E-9	166	217	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 356 aa Download sequence Send to blast
MEIIEEMIEI PRLNDNLGLN IPWLHGGLFR KRLTSSPLHS EPAGKQGNTG PNLENYFTRL 60 VQGFEPVESC VTAISELKPG GNIDTFNALH SHSDTAEDGI SDTTQEDQQN AISMAVPAAD 120 AGKGEDQQNA ISMAVPAADA GKGRKRRRLK VSKNSEEVLS QRITHIEVER NRRKQMNAHL 180 DVLRSLIPQS YIQRGDQASI IGGAIDLVKE LEQILQSLQF QKIKRENADR TDPKNCLSII 240 PPHQLFAPCN SKCVVDTSSS QLREAEDKSS IADIEVTLIE THGSLKILSK KKHGQLLKII 300 TALEGFHMTI LHLNITSMDE AVLFSFNVKV EDECPLTSAN DIARSLHQIL RIVHAC

Sequence ? help Back to Top

Protein Sequence Length: 356 aa Download sequence Send to blast

MEIIEEMIEI PRLNDNLGLN IPWLHGGLFR KRLTSSPLHS EPAGKQGNTG PNLENYFTRL  60
VQGFEPVESC VTAISELKPG GNIDTFNALH SHSDTAEDGI SDTTQEDQQN AISMAVPAAD  120
AGKGEDQQNA ISMAVPAADA GKGRKRRRLK VSKNSEEVLS QRITHIEVER NRRKQMNAHL  180
DVLRSLIPQS YIQRGDQASI IGGAIDLVKE LEQILQSLQF QKIKRENADR TDPKNCLSII  240
PPHQLFAPCN SKCVVDTSSS QLREAEDKSS IADIEVTLIE THGSLKILSK KKHGQLLKII  300
TALEGFHMTI LHLNITSMDE AVLFSFNVKV EDECPLTSAN DIARSLHQIL RIVHAC

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	143	147	RKRRR
2	144	148	KRRRL

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269\|PubMed:17088607, ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267, ECO:0000269\|PubMed:24571519, ECO:0000269\|PubMed:24654956}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269\|PubMed:22442411}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	BT117675	0.0	BT117675.1 Picea glauca clone GQ03907_D16 mRNA sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010272971.1	1e-68	PREDICTED: transcription factor bHLH96
Swissprot	Q56YJ8	4e-58	FAMA_ARATH; Transcription factor FAMA
TrEMBL	B8LLL6	6e-77	B8LLL6_PICSI; Uncharacterized protein
STRING	XP_010272971.1	5e-68	(Nelumbo nucifera)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Representative plant	OGRP253	15	131

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G24140.1	3e-58	bHLH family protein

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Matos JL, et al. Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] Chen L, et al. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] Li X,Yang R,Chen H The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]