PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Oropetium_20150105_11375A
Organism
Oropetium thomaeum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Chloridoideae; Cynodonteae; Tripogoninae; Oropetium
Family E2F/DP
Protein Properties Length: 458aa    MW: 49741.2 Da    PI: 4.8651
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Oropetium_20150105_11375AgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.21e-26145210171
                    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                                r+++sL+llt+kf++ll+++++gi++ln++a+ L   +v  ++RRiYDi+NVLe+++liek+ kn+irwkg
  Oropetium_20150105_11375A 145 RYDSSLGLLTKKFINLLKQAPDGILDLNNAAEIL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWKG 210
                                6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-28142212IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-35145210IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467858.71E-18145208IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023194.0E-24147210IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440743.92E-26236319No hitNo description
PfamPF164212.7E-26237317IPR032198E2F transcription factor, CC-MB domain
CDDcd146601.61E-39237319No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 458 aa     Download sequence    Send to blast
MSGGSGRPPA AQKILQSLRP PFAFXXXXXX XXXXXDDYHR FPAAPGAASA SASPAAATSG  60
GVGADSIEEG LVIRTPLKRK AASEENDAAE SSECMIISSP MLTPVSGKAV KTSKSKAKNN  120
KTGPQTPTSN VGSPLNPSTP AGTCRYDSSL GLLTKKFINL LKQAPDGILD LNNAAEILEV  180
QKRRIYDITN VLEGIGLIEK TLKNRIRWKG LDDSGPELDN GVSALQVFVS VNLFSSDMRE  240
KLRRLTEDEN NQRWLYVTED DIKGLPCFQN ETLIAIKAPH GTTLEVPDPD EVAGEYLQRR  300
YRIVLRSTMG PIDVYLVSQF DEKVEDLGGA AAPAKHANVP RRQPIEDFNT MNAGQSSTSM  360
DVAQNVQHIQ KIPQDPSASH DFGGMTRIIP SDDTEADYWL LTEGDVSITD MWKTAPEVQW  420
DQIDFLSEEV STPRAHNQQA VVAVGGPQMQ IPSIDKP*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-23137211274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapOropetium_20150105_11375A
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004952668.10.0transcription factor E2FA
SwissprotQ9FNY01e-114E2FA_ARATH; Transcription factor E2FA
SwissprotQ9FV711e-115E2FB_ARATH; Transcription factor E2FB
TrEMBLK3YS640.0K3YS64_SETIT; Uncharacterized protein
STRINGSi017108m0.0(Setaria italica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP62537148
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.31e-105E2F transcription factor 1
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]
  2. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  3. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  4. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]