PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ote100227480071
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Ocimum
Family bHLH
Protein Properties Length: 291aa    MW: 32762.5 Da    PI: 7.5033
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ote100227480071genomeOteDB-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH438e-14100151155
                                   CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                           HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                                   +r++h ++Er+RR+++N+ ++ Lr+l+P++   +  + + a+i+  A+e++++L+
  Ote100227480071|100227480071 100 QRMTHIAVERNRRKQMNEHLQILRSLMPTS---YIHRGDQASIVGGAIEFVRELE 151
                                   79****************************...9*****************9995 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.108.0E-1498154IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000839.63E-1398155No hitNo description
SuperFamilySSF474595.5E-1699172IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.19999150IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000104.1E-11100151IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003536.6E-10105156IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 291 aa     Download sequence    Send to blast
MSFYDECSQM MDCILNIPPS THLCCSNTFK TSNLSDQMQL EEAASKLALN EAKSCGEENE  60
ARTKPKPAVE KVGKSPVVKK AKNKRKRARA TKTSEEIERQ RMTHIAVERN RRKQMNEHLQ  120
ILRSLMPTSY IHRGDQASIV GGAIEFVREL EQLLQCLQSV KRRKLYEDEQ QQQSHQEPLM  180
FPTIPVDTND TDETAESKSC LAEVGVKLSG LFGLIKIVSE TRPGQLIKNI AAIEHLHLHI  240
LQTNVTTIEH NLVCSFIFQM SGEARLTAEE ISNSIQQILS CVHANSSSLM S
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011091423.13e-92transcription factor FAMA isoform X3
SwissprotQ56YJ85e-79FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A068TT286e-92A0A068TT28_COFCA; Uncharacterized protein
TrEMBLA0A0H3YC305e-92A0A0H3YC30_SALMI; Basic helix-loop-helix transcription factor
STRINGXP_009795997.12e-85(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA46572341
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]