PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ote100172530041
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Ocimum
Family ARF
Protein Properties Length: 565aa    MW: 63526.4 Da    PI: 9.1796
Description ARF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ote100172530041genomeOteDB-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1B373.52.6e-23130231199
                                   EEEE-..-HHHHTT-EE--HHH.HTT.......---..--SEEEEEETTS-EEEEEE..EEETTEEEE-TTHHHHHHHHT- CS
                            B3   1 ffkvltpsdvlksgrlvlpkkfaeeh.......ggkkeesktltledesgrsWevkliyrkksgryvltkGWkeFvkangL 74 
                                   f+k+lt sd++++g +++p++ ae+        +   +  ++l+ +d++  +W++++i+r++++r++lt+GW+ Fv+a++L
  Ote100172530041|100172530041 130 FCKTLTASDTSTHGGFSVPRRAAEKVfppldfsQT--PPAQELIARDLHDVEWKFRHIFRGQPKRHLLTTGWSVFVSAKRL 208
                                   99*****************************7444..44459*************************************** PP

                                   -TT-EEEEEE-SSSEE..EEEEE-S CS
                            B3  75 kegDfvvFkldgrsefelvvkvfrk 99 
                                    +gD+v+F   ++++ +l+++++r+
  Ote100172530041|100172530041 209 VAGDSVLFI--WNEKNQLFLGIRRA 231
                                   *********..8889999***9986 PP

2Auxin_resp119.72.3e-39256339183
                    Auxin_resp   1 aahaastksvFevvYnPrastseFvvkvekvekalk.vkvsvGmRfkmafetedsserrlsGtvvgvsdldpvrWpnSkWr 80 
                                   aahaast+s F+v+YnPras+seFv++++k+ ka++ ++vsvGmRf+m fete+ss rr++Gt++g+ dldpvrW nS+Wr
  Ote100172530041|100172530041 256 AAHAASTNSCFTVFYNPRASPSEFVIPLSKYAKAVYhTRVSVGMRFRMLFETEESSVRRYMGTITGIGDLDPVRWANSHWR 336
                                   79*********************************9789****************************************** PP

                    Auxin_resp  81 sLk 83 
                                   s+k
  Ote100172530041|100172530041 337 SVK 339
                                   985 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019364.45E-49115259IPR015300DNA-binding pseudobarrel domain
Gene3DG3DSA:2.40.330.108.4E-41125245IPR015300DNA-binding pseudobarrel domain
CDDcd100171.08E-21129225No hitNo description
SMARTSM010191.7E-23130232IPR003340B3 DNA binding domain
PfamPF023621.2E-21130231IPR003340B3 DNA binding domain
PROSITE profilePS5086312.21130232IPR003340B3 DNA binding domain
PfamPF065071.3E-34256339IPR010525Auxin response factor
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009725Biological Processresponse to hormone
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 565 aa     Download sequence    Send to blast
MNTMKLSASE MGQQAHEGEK KCLNSELWHA CAGPLVSLPT VGSRVVYFPQ GHSEQVAATT  60
NKEVDAHIPN YPSLQPQLIC QLHNVTMHAD VETDEVYAQM TLQPLTPQEQ KDAYLPVELG  120
IPSCQPTNYF CKTLTASDTS THGGFSVPRR AAEKVFPPLD FSQTPPAQEL IARDLHDVEW  180
KFRHIFRGQP KRHLLTTGWS VFVSAKRLVA GDSVLFIWNE KNQLFLGIRR AARPQTVMPS  240
SVLSSDSMHI GLLAAAAHAA STNSCFTVFY NPRASPSEFV IPLSKYAKAV YHTRVSVGMR  300
FRMLFETEES SVRRYMGTIT GIGDLDPVRW ANSHWRSVKV GWDESTAGER QPRVSLWEIE  360
PLTTFPMYPS LFPLRLKRPW YPGASSFQDA GSDTINGMQW LRGEASEQGF NSINFQSVGM  420
LPWMQQRFDP TGVRNDLNQQ YQALLAAGLQ NFGSGDLPKH QLTTFQQPIH YLQHAGSQNP  480
QSQQQNVIQP SVSSHTLPLP TQMLSDNMQR XXXXXXXXXX SRQPNRRKSA ASYLSGSIYR  540
TRSSEAPTRY SFPFIYKTGT SKLRD
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4ldu_A1e-159136034388Auxin response factor 5
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtAuxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Regulates both stamen and gynoecium maturation. Promotes jasmonic acid production. Partially redundant with ARF6. Involved in fruit initiation. Acts as an inhibitor to stop further carpel development in the absence of fertilization and the generation of signals required to initiate fruit and seed development. {ECO:0000269|PubMed:12036261, ECO:0000269|PubMed:16107481, ECO:0000269|PubMed:16829592}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by miR167. {ECO:0000269|PubMed:17021043}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027075605.10.0auxin response factor 8-like
SwissprotQ9FGV10.0ARFH_ARATH; Auxin response factor 8
TrEMBLA0A2G9H4W80.0A0A2G9H4W8_9LAMI; Auxin response factor
STRINGXP_009612885.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA38572339
Publications ? help Back to Top
  1. Liu N, et al.
    Down-regulation of AUXIN RESPONSE FACTORS 6 and 8 by microRNA 167 leads to floral development defects and female sterility in tomato.
    J. Exp. Bot., 2014. 65(9): p. 2507-20
    [PMID:24723401]
  2. Minato N, et al.
    The phytoplasmal virulence factor TENGU causes plant sterility by downregulating of the jasmonic acid and auxin pathways.
    Sci Rep, 2014. 4: p. 7399
    [PMID:25492247]
  3. Ortega-Amaro MA, et al.
    Overexpression of AtGRDP2, a novel glycine-rich domain protein, accelerates plant growth and improves stress tolerance.
    Front Plant Sci, 2014. 5: p. 782
    [PMID:25653657]
  4. Wang Y, et al.
    MicroRNA167-Directed Regulation of the Auxin Response Factors GmARF8a and GmARF8b Is Required for Soybean Nodulation and Lateral Root Development.
    Plant Physiol., 2015. 168(3): p. 984-99
    [PMID:25941314]
  5. Barik S, et al.
    Coevolution Pattern and Functional Conservation or Divergence of miR167s and their targets across Diverse Plant Species.
    Sci Rep, 2015. 5: p. 14611
    [PMID:26459056]
  6. Pashkovskiy PP,Kartashov AV,Zlobin IE,Pogosyan SI,Kuznetsov VV
    Blue light alters miR167 expression and microRNA-targeted auxin response factor genes in Arabidopsis thaliana plants.
    Plant Physiol. Biochem., 2016. 104: p. 146-54
    [PMID:27031426]
  7. Mlotshwa S,Pruss GJ,MacArthur JL,Reed JW,Vance V
    Developmental Defects Mediated by the P1/HC-Pro Potyviral Silencing Suppressor Are Not Due to Misregulation of AUXIN RESPONSE FACTOR 8.
    Plant Physiol., 2016. 172(3): p. 1853-1861
    [PMID:27688620]
  8. Wójcikowska B,Gaj MD
    Expression profiling of AUXIN RESPONSE FACTOR genes during somatic embryogenesis induction in Arabidopsis.
    Plant Cell Rep., 2017. 36(6): p. 843-858
    [PMID:28255787]
  9. Zhang GZ, et al.
    Ectopic expression of UGT84A2 delayed flowering by indole-3-butyric acid-mediated transcriptional repression of ARF6 and ARF8 genes in Arabidopsis.
    Plant Cell Rep., 2017. 36(12): p. 1995-2006
    [PMID:29027578]
  10. Zheng K, et al.
    Involvement of PACLOBUTRAZOL RESISTANCE6/KIDARI, an Atypical bHLH Transcription Factor, in Auxin Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1813
    [PMID:29114256]
  11. Liu Z, et al.
    ARF2-ARF4 and ARF5 are Essential for Female and Male Gametophyte Development in Arabidopsis.
    Plant Cell Physiol., 2018. 59(1): p. 179-189
    [PMID:29145642]
  12. Ghelli R, et al.
    A Newly Identified Flower-Specific Splice Variant of AUXIN RESPONSE FACTOR8 Regulates Stamen Elongation and Endothecium Lignification in Arabidopsis.
    Plant Cell, 2018. 30(3): p. 620-637
    [PMID:29514943]