PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Ote100134140101

Organism

Ocimum tenuiflorum

Taxonomic ID

204149

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Ocimum

Family

bHLH

Protein Properties

Length: 372aa MW: 42006.9 Da PI: 5.0171

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Ote100134140101	genome	OteDB	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	40.3	5.5e-13	182	233	1	55
CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +r++h ++Er+RR+++N+ + Lr+l+P++ + ++ + a+i A+e++++L+ Ote100134140101\|100134140101 182 QRMTHIAVERNRRKQMNEHLRVLRSLMPSS---YVQRGDQASIIGGAIEFVRELE 233 79**************************...9***************9995 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
CDD	cd00083	5.14E-13	180	237	No hit	No description
Gene3D	G3DSA:4.10.280.10	6.1E-14	180	236	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	15.288	181	232	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	2.22E-16	181	246	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	2.8E-10	182	233	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	3.0E-9	187	238	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0010377	Biological Process	guard cell fate commitment
GO:0045597	Biological Process	positive regulation of cell differentiation
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051782	Biological Process	negative regulation of cell division
GO:0005634	Cellular Component	nucleus
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 372 aa Download sequence Send to blast
MDKEGNYLGN FHGLGYNSLD VHNEEEEEGI NQEIGATSNA QNSNQIVDYM LHNQAPHHHQ 60 PPLLPSNFCS SNSFDKLSFA DVMQFADFGP KLGLNQTKTP EEEAGLDPVY FLKFPVLNDH 120 HKMQDEEDNQ LSLMADDDQE RGGKGDDESV QLRFVDKSPQ AEGKSKRKRP RTVKTVEEVE 180 SQRMTHIAVE RNRRKQMNEH LRVLRSLMPS SYVQRGDQAS IIGGAIEFVR ELEQLLQCLE 240 SQKRRRLYGD GARSVGDSSM AAQPQMYENV EYEGGVQEEM AESKSCLADV EVKLLGFDGL 300 IKILSRRRHG QLIKTIAALE DLHLTILHTN ITTIEQTVLY SFNISGEARF TAEDLANSVQ 360 QIFSFIHANT AI

Sequence ? help Back to Top

Protein Sequence Length: 372 aa Download sequence Send to blast

MDKEGNYLGN FHGLGYNSLD VHNEEEEEGI NQEIGATSNA QNSNQIVDYM LHNQAPHHHQ  60
PPLLPSNFCS SNSFDKLSFA DVMQFADFGP KLGLNQTKTP EEEAGLDPVY FLKFPVLNDH  120
HKMQDEEDNQ LSLMADDDQE RGGKGDDESV QLRFVDKSPQ AEGKSKRKRP RTVKTVEEVE  180
SQRMTHIAVE RNRRKQMNEH LRVLRSLMPS SYVQRGDQAS IIGGAIEFVR ELEQLLQCLE  240
SQKRRRLYGD GARSVGDSSM AAQPQMYENV EYEGGVQEEM AESKSCLADV EVKLLGFDGL  300
IKILSRRRHG QLIKTIAALE DLHLTILHTN ITTIEQTVLY SFNISGEARF TAEDLANSVQ  360
QIFSFIHANT AI

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269\|PubMed:17088607, ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267, ECO:0000269\|PubMed:24571519, ECO:0000269\|PubMed:24654956}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269\|PubMed:22442411}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011091423.1	0.0	transcription factor FAMA isoform X3
Swissprot	Q56YJ8	1e-135	FAMA_ARATH; Transcription factor FAMA
TrEMBL	A0A0H3YC69	0.0	A0A0H3YC69_SALMI; Basic helix-loop-helix transcription factor
STRING	cassava4.1_024031m	1e-165	(Manihot esculenta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA4657	23	41

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Matos JL, et al. Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] Chen L, et al. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] Li X,Yang R,Chen H The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]