PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

XP_009628533.1

Organism

Nicotiana tomentosiformis

Taxonomic ID

4098

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

bHLH

Protein Properties

Length: 283aa MW: 32348.9 Da PI: 5.0179

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_009628533.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	41.1	3.1e-13	87	138	1	55
CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +r++h e+Er+RR+++N+ + Lr+l+P++ + ++ + a+i A+e++++L+ XP_009628533.1 87 QRMTHIEVERNRRKQMNEHLLVLRSLMPSS---YVQRGDQASIIGGAIEFVRELE 138 79**************************...9***************9995 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:4.10.280.10	1.3E-13	85	141	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	1.50E-12	85	142	No hit	No description
SuperFamily	SSF47459	4.19E-17	85	165	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	15.11	86	137	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	1.9E-10	87	138	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	2.2E-9	92	143	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd04873	0.00235	209	273	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 283 aa Download sequence Send to blast
MEEKENNQPY LPTISPSLNH QNPEMVNEEA MMVSQIEEKF IEFSDKVENA TQLKFLIGEN 60 LENSQANESK KKRKRTRIKS SEEVENQRMT HIEVERNRRK QMNEHLLVLR SLMPSSYVQR 120 GDQASIIGGA IEFVRELEQL LQCLESQKRR KLYGDDSLLM EIQNPSQPPF FDPLPLANEL 180 YEGGIQEEIA ESKSCLADVE VKLLGFNAMI KILSKRRPGQ LITTISALED LQLNIIHTNI 240 TTIEQTVLYS FNVKIAGESK FTADGIANLV QQIFSFIHAN NAI

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	70	75	KKRKRT
2	87	98	RMTHIEVERNRR

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269\|PubMed:17088607, ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267, ECO:0000269\|PubMed:24571519, ECO:0000269\|PubMed:24654956}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269\|PubMed:22442411}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009628530.1	0.0	PREDICTED: transcription factor FAMA-like isoform X2
Refseq	XP_009628531.1	0.0	PREDICTED: transcription factor FAMA-like isoform X2
Refseq	XP_009628533.1	0.0	PREDICTED: transcription factor FAMA-like isoform X2
Swissprot	Q56YJ8	1e-102	FAMA_ARATH; Transcription factor FAMA
TrEMBL	A0A1S4BHN6	0.0	A0A1S4BHN6_TOBAC; transcription factor FAMA-like isoform X2
STRING	XP_009628530.1	0.0	(Nicotiana tomentosiformis)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G24140.1	2e-85	bHLH family protein

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Matos JL, et al. Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] Chen L, et al. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] Li X,Yang R,Chen H The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]