PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009623945.1
Organism
Nicotiana tomentosiformis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 438aa    MW: 48446.8 Da    PI: 4.4228
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009623945.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.22.4e-27118183171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  XP_009623945.1 118 RYDSSLGLLTKKFINLIKHAEDGVLDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 183
                     6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.3E-29116185IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.81E-17118181IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.2E-35118183IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.1E-24120183IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146606.42E-44194300No hitNo description
SuperFamilySSF1440742.28E-31196300No hitNo description
PfamPF164213.6E-31199298IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 438 aa     Download sequence    Send to blast
MQQPHRQQRE LPFTSSKPPL GDYHRFSTDP LQQPEAILVK STPLKRKSET ANYKQGVGVI  60
TDSGYADVSS PTQTPVSGKV GKAQKVPRTS KARSASQAAT SNIGSPSGNN ATPVGPCRYD  120
SSLGLLTKKF INLIKHAEDG VLDLNKAADT LEVQKRRIYD ITNVLEGIGL IEKKLKNRIQ  180
WKGLDVSRPG DVDDSVTSLQ AEVENLTIEE RRLDEQTREM QERLTDLCED ENNQRWLLVT  240
EDDIKSLPCL QNETLIAIKA PHGTTLEVPD PDEAVDYPQR RYRIVLRSTM GPIDVYLVSQ  300
FEEKIEEINA VEAPSAMPST SGFNENETAT LPTEESGGVD GRMDEKENQS VCADVGTSQD  360
FASGIMKIVS DVDNEEDYWL LSDADVSITD IWRADSVLDW NELNAIHEDY SIDNVSTPRA  420
QTPPSGTTEL PSANTTRS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-26113184274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0253470.0AB025347.1 Nicotiana tabacum mRNA for transcription factor, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009623945.10.0PREDICTED: transcription factor E2FB isoform X2
SwissprotQ9FV711e-149E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A1S4A2450.0A0A1S4A245_TOBAC; transcription factor E2FB-like
STRINGXP_009623945.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-151E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]