PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009615455.1
Organism
Nicotiana tomentosiformis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 354aa    MW: 39460.6 Da    PI: 9.7346
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009615455.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP76.82.2e-242085171
         E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    rkeksL+ll+++flkl+ ++  + + l+++a++L    v  +rRRiYDi+N+Le+++++++k+kn+++w+g
  XP_009615455.1 20 RKEKSLGLLCSNFLKLCDREGVDSIGLDNAADQL---GV--ERRRIYDIVNILESVGVLSRKAKNQYKWNG 85
                    79*****************999************...**..****************************98 PP
2E2F_TDP72.83.8e-23142221170
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwk 70 
                     rkeksL +l+q+f+kl+++s+ + ++l+++a++L+ +      +k+k RR+YDi+NV+ ++nliek     + k+++rw+
  XP_009615455.1 142 RKEKSLMILAQNFVKLFHCSDVDLISLDKAASALLGDmhdpmAMKTKTRRLYDIANVFVSMNLIEKirspdNGKPAFRWI 221
                     79********************************************************************99*******7 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.1E-251886IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467855.24E-161983IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.5E-272085IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.1E-202185IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.8E-19139222IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.4E-24142222IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.6E-18143221IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.27E-11144221IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 354 aa     Download sequence    Send to blast
MSSSVNPEEA QWKNPNIYSR KEKSLGLLCS NFLKLCDREG VDSIGLDNAA DQLGVERRRI  60
YDIVNILESV GVLSRKAKNQ YKWNGFSAIP KAVDLLKKEG LKDQSSVSST SHNVANVIAC  120
SHSDLKEKGQ GKTSGSHKID NRKEKSLMIL AQNFVKLFHC SDVDLISLDK AASALLGDMH  180
DPMAMKTKTR RLYDIANVFV SMNLIEKIRS PDNGKPAFRW IAWKENPRTG SPATSKSDDS  240
KSRTFGAEIT NTISKRYRAD SSSDLVSNGQ VKRLKVAKDD ELKDKNQEMS TERLNGHGTM  300
DFVFGPFGPA SLPKAGVSGK ENLKQTQNWE DLASTYRPQY QNKGGIEHIQ QEYI
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A4e-33192083222Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHG9754411e-129HG975441.1 Solanum pennellii chromosome ch02, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009615455.10.0PREDICTED: E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ42e-88E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A1S3YMI40.0A0A1S3YMI4_TOBAC; E2F transcription factor-like E2FE isoform X2
STRINGXP_009615454.10.0(Nicotiana tomentosiformis)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.11e-92DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]