PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009610968.1
Organism
Nicotiana tomentosiformis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family AP2
Protein Properties Length: 541aa    MW: 60163.8 Da    PI: 6.1363
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009610968.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP244.15.3e-14167226155
             AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng..kr.krfslgkfgtaeeAakaaiaarkkleg 55 
                     s y+GV++++++gr++A+++d  +   g  ++ ++++lg ++ +e+Aa+ ++ a++k++g
  XP_009610968.1 167 SIYRGVTRHRWTGRYEAHLWDnSCRrEGqsRKgRQVYLGGYDKEEKAARSYDLAALKYWG 226
                     57*******************666664477446*************************98 PP
2AP250.84e-16271320355
             AP2   3 ykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                     y+GV+++++ grW A+I  +     +k  +lg+fgt+eeAa+a++ a+ k++g
  XP_009610968.1 271 YRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFGTEEEAAEAYDVAAIKFRG 320
                     9***************988532...5************************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000185.62E-22167236No hitNo description
PfamPF008474.7E-11167226IPR001471AP2/ERF domain
SuperFamilySSF541712.81E-16167236IPR016177DNA-binding domain
Gene3DG3DSA:3.30.730.108.8E-15168234IPR001471AP2/ERF domain
SMARTSM003807.4E-29168240IPR001471AP2/ERF domain
PROSITE profilePS5103218.953168234IPR001471AP2/ERF domain
PRINTSPR003671.4E-5169180IPR001471AP2/ERF domain
CDDcd000185.47E-24269328No hitNo description
SuperFamilySSF541719.15E-18269329IPR016177DNA-binding domain
Gene3DG3DSA:3.30.730.101.6E-17270328IPR001471AP2/ERF domain
SMARTSM003808.1E-31270334IPR001471AP2/ERF domain
PROSITE profilePS5103218.979270328IPR001471AP2/ERF domain
PfamPF008472.7E-11271320IPR001471AP2/ERF domain
PRINTSPR003671.4E-5310330IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 541 aa     Download sequence    Send to blast
MGSMNSNNWL SFHLSPHLQT TESRSLGLVT ETIDNPFQNQ EWNFSETQGG NEVPKVADFL  60
GVSKSGHESE LVSYSEIQAN DNSDYLFPNT NLMPMLNVTY DLQENACNMQ SLTLSMGSGK  120
NSTSETCASP SANATAGASS TSGENSNTSI VEAAPRRTSD TFGQRTSIYR GVTRHRWTGR  180
YEAHLWDNSC RREGQSRKGR QVYLGGYDKE EKAARSYDLA ALKYWGTSTT TNFPINNYEK  240
EVEEMKHMTR QESIASIRRK STGFSRGASM YRGVTRHHQH GRWQARIGRV AGNKDLYLGT  300
FGTEEEAAEA YDVAAIKFRG LCAVTNFEMN RYDVKAILES NTLPVGGGAA KRLKETQAFE  360
SSRKRDQEMI SLNSSTTFHQ YENSNNSGVA FQTYPLMQQP LLTTLQNQDF SSQFHQGYIQ  420
THLQLHHQQS HQMYNDYLQS NNPVFLHGLM NNMGSSSSVI DNNGGSSSGS YSTGGYHNNT  480
TGIGMTSNSP SGGVSAHEEI AMVKVDYDMP YTGWSGESSV QESNPGGFNM WNDREIEDID  540
L
Functional Description ? help Back to Top
Source Description
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). Master regulator of basal/root fate. Essential for root quiescent center (QC) and columella specification, stem cell activity, as well as for establishment of the stem cell niche during embryogenesis. Modulates the root polar auxin transport by regulating the distribution of PIN genes. Essential role in respecifying pattern and polarity in damaged roots. Direct target of the transcriptional corepressor TPL. Expression levels and patterns regulated post-transcriptionally by root meristem growth factors (RGFs). {ECO:0000250, ECO:0000269|PubMed:15454085, ECO:0000269|PubMed:15635403, ECO:0000269|PubMed:16424342, ECO:0000269|PubMed:20190735}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By auxin accumulation. {ECO:0000269|PubMed:15454085}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009610968.10.0PREDICTED: AP2-like ethylene-responsive transcription factor PLT2 isoform X2
SwissprotQ5YGP70.0PLET2_ARATH; AP2-like ethylene-responsive transcription factor PLT2
TrEMBLA0A1S4AVA50.0A0A1S4AVA5_TOBAC; AP2-like ethylene-responsive transcription factor PLT2 isoform X2
STRINGXP_009610966.10.0(Nicotiana tomentosiformis)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G51190.10.0AP2 family protein
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Lee DK,Sieburth LE
    The bps signal: embryonic arrest from an auxin-independent mechanism in bypass triple mutants.
    Plant Signal Behav, 2012. 7(6): p. 698-700
    [PMID:22580686]
  3. Hong LW,Yan DW,Liu WC,Chen HG,Lu YT
    TIME FOR COFFEE controls root meristem size by changes in auxin accumulation in Arabidopsis.
    J. Exp. Bot., 2014. 65(1): p. 275-86
    [PMID:24277277]
  4. Tian H,Jia Y,Niu T,Yu Q,Ding Z
    The key players of the primary root growth and development also function in lateral roots in Arabidopsis.
    Plant Cell Rep., 2014. 33(5): p. 745-53
    [PMID:24504658]
  5. Zhao Q, et al.
    Sulfur nutrient availability regulates root elongation by affecting root indole-3-acetic acid levels and the stem cell niche.
    J Integr Plant Biol, 2014. 56(12): p. 1151-63
    [PMID:24831283]
  6. Huang JB, et al.
    ROP3 GTPase contributes to polar auxin transport and auxin responses and is important for embryogenesis and seedling growth in Arabidopsis.
    Plant Cell, 2014. 26(9): p. 3501-18
    [PMID:25217509]
  7. Yang S, et al.
    The Arabidopsis SWI2/SNF2 Chromatin Remodeling ATPase BRAHMA Targets Directly to PINs and Is Required for Root Stem Cell Niche Maintenance.
    Plant Cell, 2015. 27(6): p. 1670-80
    [PMID:25991732]
  8. Jia Y, et al.
    The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development.
    J. Exp. Bot., 2015. 66(15): p. 4631-42
    [PMID:25998905]
  9. Zhang M, et al.
    A tetratricopeptide repeat domain-containing protein SSR1 located in mitochondria is involved in root development and auxin polar transport in Arabidopsis.
    Plant J., 2015. 83(4): p. 582-99
    [PMID:26072661]
  10. Shinohara H,Mori A,Yasue N,Sumida K,Matsubayashi Y
    Identification of three LRR-RKs involved in perception of root meristem growth factor in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2016. 113(14): p. 3897-902
    [PMID:27001831]
  11. Ou Y, et al.
    RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana.
    Cell Res., 2016. 26(6): p. 686-98
    [PMID:27229312]
  12. Santuari L, et al.
    The PLETHORA Gene Regulatory Network Guides Growth and Cell Differentiation in Arabidopsis Roots.
    Plant Cell, 2016. 28(12): p. 2937-2951
    [PMID:27920338]
  13. Promchuea S,Zhu Y,Chen Z,Zhang J,Gong Z
    ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis .
    J Integr Plant Biol, 2017. 59(1): p. 30-43
    [PMID:28074634]
  14. Du Y,Scheres B
    PLETHORA transcription factors orchestrate de novo organ patterning during Arabidopsis lateral root outgrowth.
    Proc. Natl. Acad. Sci. U.S.A., 2017. 114(44): p. 11709-11714
    [PMID:29078398]
  15. Bustillo-Avendaño E, et al.
    Regulation of Hormonal Control, Cell Reprogramming, and Patterning during De Novo Root Organogenesis.
    Plant Physiol., 2018. 176(2): p. 1709-1727
    [PMID:29233938]