PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009607525.1
Organism
Nicotiana tomentosiformis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 382aa    MW: 42929.5 Da    PI: 8.734
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009607525.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.41.2e-231782171
         E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    rk+ksL+ll+++fl+l++++  +++ l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  XP_009607525.1 17 RKQKSLGLLCSNFLSLYNREGIETIGLDDAARRL---GV--ERRRIYDIVNVLESIGVLARKAKNRYSWKG 82
                    79*****************999************...**..****************************98 PP
2E2F_TDP74.88.8e-24149229171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                     r+eksL+lltq+f+kl+ +++ ++++l+e+ak L+ +      +++k+RR+YDi+NVL++++ iek     ++k+++rw g
  XP_009607525.1 149 RREKSLGLLTQNFVKLFLCTDVDMICLDEAAKILLGDgrppaMTRTKVRRLYDIANVLSSMKFIEKthhpeTRKPAFRWLG 229
                     689**************************************99999*********************99999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.2E-261383IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.48E-151780IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.8E-281782IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.5E-201882IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.104.1E-23144230IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.0E-31149229IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.31E-11151230IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023197.1E-18151229IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 382 aa     Download sequence    Send to blast
MSLASDPSKD SRSTYCRKQK SLGLLCSNFL SLYNREGIET IGLDDAARRL GVERRRIYDI  60
VNVLESIGVL ARKAKNRYSW KGFGAIPWTL QQLKEEGLKE NVSGFDGSSS AKGSDDDDDD  120
SDSKPIVSSH TETLNPSSNF AAASKSDNRR EKSLGLLTQN FVKLFLCTDV DMICLDEAAK  180
ILLGDGRPPA MTRTKVRRLY DIANVLSSMK FIEKTHHPET RKPAFRWLGM RERSDDKSVD  240
TLGATESKKR VFGTELTNTT IKRSRVALPM DGISDEATRK QLLTEVKCEN LENEIHCPKQ  300
EPGLTASKKS YHFGPFAPPS LAQAEASDAD RMKRVHDWES LASTYRPQYH NQALKDLFAH  360
YVEAWKSWYL EVAGKNPIQL IS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-37172214228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHG9755151e-134HG975515.1 Solanum lycopersicum chromosome ch03, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009607525.10.0PREDICTED: E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-121E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A1J6KF880.0A0A1J6KF88_NICAT; E2f transcription factor-like e2fe
STRINGXP_009607525.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-121DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]