PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

XP_009606865.1

Organism

Nicotiana tomentosiformis

Taxonomic ID

4098

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

E2F/DP

Protein Properties

Length: 232aa MW: 25216.6 Da PI: 9.906

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_009606865.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	87.9	7.4e-28	128	193	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+g+++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg XP_009606865.1 128 RYDSSLGLLTKKFINLIKHAEDGMLDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 193 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	5.7E-30	126	195	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	6.8E-18	128	191	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.9E-34	128	193	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	5.6E-25	130	193	IPR003316	E2F/DP family, winged-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 232 aa Download sequence Send to blast
MQPQQQQQQP SLKRQLQFSS IKPAFGDYHR FSTDPVHCSS QEPPAGIVVK TPPLKRKSAA 60 ANYGQGVGDQ NPVSEYANVN SPVQTPMSGK AGNTQKIPKT SKARSASQAV ASNAGSPSGN 120 VTPVGPCRYD SSLGLLTKKF INLIKHAEDG MLDLNKAADT LEVQKRRIYD ITNVLEGIGL 180 IEKKLKNRIQ WKGLDVSKPG EADESIASLQ VRTVTPMADV FFLLSFETHL TD

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	5e-28	123	194	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	HE653923	0.0	HE653923.1 Nicotiana tabacum mRNA for transcription factor E2FB (E2FB gene), cultivar Samsun nn.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009606865.1	1e-173	PREDICTED: transcription factor E2FB-like
Swissprot	Q9FV71	2e-66	E2FB_ARATH; Transcription factor E2FB
TrEMBL	M5BCF3	1e-149	M5BCF3_TOBAC; Transcription factor E2FB
STRING	XP_009606865.1	1e-172	(Nicotiana tomentosiformis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1077	24	84

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	2e-66	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]