PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009602096.1
Organism
Nicotiana tomentosiformis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 376aa    MW: 42265.4 Da    PI: 4.2033
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009602096.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.81.6e-2754119171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  XP_009602096.1  54 RYDSSLGLLTKKFINLIKHAEDGMLDLNQAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 119
                     6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.0E-3052121IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.29E-1754117IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.6E-3454119IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023199.7E-2556119IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440741.07E-33133236No hitNo description
CDDcd146605.26E-46135236No hitNo description
PfamPF164211.7E-33135234IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 376 aa     Download sequence    Send to blast
MWPIVHLERQ CLEKEEEQMD GQEPQKAINL DLQLLSLMLV RLGSPSPLTP ANCRYDSSLG  60
LLTKKFINLI KHAEDGMLDL NQAADTLEVQ KRRIYDITNV LEGIGLIEKK LKNRIQWKGV  120
DASRPGEVDN DAAILKAETE SLSMEERRLD DQVRELQEKL RDMSEDEDNQ KWLFVTEEDI  180
KSLPCFQNET LIAVKAPHGT TLEVPDPDEA VDYPQRRYRI ILRSTMGPID VYLVSQFEEK  240
FEEMNSVEPS MAIPVASSSG SKDNPAMERS TLSNSVTENE VQTQNVDQLS SDLGTSQDYG  300
GGMMKVVPSD VDNDADYWLL SDAHVSITNM WEADPAVEWD GENLLHEFGI ADLGTPRAHT  360
PSAVTDVPTP MNVPPR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-2547120274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00661PBMTransfer from Pp3c1_6880Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC2397383e-77AC239738.5 Solanum lycopersicum strain Heinz 1706 chromosome 1 clone hba-240p19 map 1, complete sequence.
GenBankHG9754403e-77HG975440.1 Solanum pennellii chromosome ch01, complete genome.
GenBankHG9755133e-77HG975513.1 Solanum lycopersicum chromosome ch01, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009789429.10.0PREDICTED: transcription factor E2FA isoform X3
SwissprotQ9FNY01e-134E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A1U7XR730.0A0A1U7XR73_NICSY; transcription factor E2FA isoform X3
STRINGXP_009602094.10.0(Nicotiana tomentosiformis)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-138E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]